Patents by Inventor Daniel W. Michael
Daniel W. Michael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240076300Abstract: The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.Type: ApplicationFiled: May 8, 2023Publication date: March 7, 2024Applicant: C4 Therapeutics, Inc.Inventors: Christopher G. Nasveschuk, Martin Duplessis, Jae Young Ahn, Alexander W. Hird, Ryan E. Michael, Kiel Lazarski, Yanke Liang, Georg Jaeschke, Antonio Ricci, Annick Goergler, Daniel Rueher
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Patent number: 5612308Abstract: Detergent compositions comprising a surfactant system that is either (1) a mixture nonionic and zwitterionic detergent surfactants; (2) a mixture of nonionic and amphoteric (non-zwitterionic) detergent surfactants; or (3) short chain nonionic detergent surfactant, the nonionic detergent surfactants preferably being short chain and/or having peaked distribution; optional hydrophobic cleaning solvent; and polycarboxylate, especially dicarboxylate, detergent builder provide superior cleaning of all of the soils commonly found in the bathroom. The compositions have a pH of from about 1 to about 5.5, preferably from about 2 to about 4 when the dicarboxylate builder is used. The compositions are in the form of aqueous liquids. Short chain peaked distribution nonionic detergent surfactants provide surprisingly superior sudsing characteristics.Type: GrantFiled: June 6, 1995Date of Patent: March 18, 1997Assignee: The Procter & Gamble CompanyInventors: Ricky A. Woo, Michel J. Carrie, William A. Cilley, Ronald A. Masters, Daniel W. Michael, Eddy Vos
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Patent number: 5604192Abstract: Detergent compositions comprising nonionic detergent surfactant; unsaturated soap, i.e., oleate and/or ricinoleate; hydrophobic cleaning solvent; and aqueous solvent system. The compositions have excellent detergency properties and excellent filming/streaking properties. Preferred soaps are specific betaaminoalkanolammonium soaps, which provide superior filming/streaking properties as compared to, e.g., sodium soap.Type: GrantFiled: December 21, 1994Date of Patent: February 18, 1997Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, Thomas A. Borcher, Sr.
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Patent number: 5583265Abstract: Detergent compositions comprising a surfactant system that is either (1) a mixture nonionic and zwitterionic detergent surfactants; (2) a mixture of nonionic and amphoteric (non-zwitterionic) detergent surfactants; or (3) short chain nonionic detergent surfactant, the nonionic detergent surfactants preferably being short chain and/or having peaked distribution; optional hydrophobic cleaning solvent; and polycarboxylate, especially dicarboxylate, detergent builder provide superior cleaning of all of the soils commonly found in the bathroom. The compositions have a pH of from about 1 to about 5.5, preferably from about 2 to about 4 when the dicarboxylate builder is used. The compositions are in the form of aqueous liquids. Short chain peaked distribution nonionic detergent surfactants provide surprisingly superior sudsing characteristics.Type: GrantFiled: June 6, 1995Date of Patent: December 10, 1996Inventors: Ricky A.-M. Woo, Michel J. Carrie, William A. Cilley, Ronald A. Masters, Daniel W. Michael, Eddy Vos
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Patent number: 5540864Abstract: Aqueous, liquid hard surface detergent compositions contain zwitterionic detergent surfactant and monoethanolamine and/or other specific beta-aminoalkanols as solvents and/or buffers for improved spotting/filming and good cleaning. Some formulas do not contain large amounts of builders and are suitable for general purpose cleaning including cleaning of glass.Type: GrantFiled: June 2, 1995Date of Patent: July 30, 1996Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5540865Abstract: Detergent compositions comprising a hydrocarbyl-amidoalkyl-enebetaine synthetic detergent surfactant; cleaning solvent; and buffer provide superior filming/streaking and good cleaning of hard to remove grease soils. Preferred compositions contain at least one cosurfactant. The compositions can be used to clean glass as well as for general cleaning purposes.Type: GrantFiled: January 13, 1995Date of Patent: July 30, 1996Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5538664Abstract: Hard surface detergent compositions comprise nonionic detergent surfactant; tripropylene glycol or short chain alkyl ether of tripropylene glycol as a hydrophobic cleaning solvent; and optional, but preferred suds control system comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present. The compositions clean vinyl no-wax flooring without rinsing and without substantial filming/streaking.Type: GrantFiled: December 29, 1993Date of Patent: July 23, 1996Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5454983Abstract: Aqueous, liquid hard surface detergent compositions contain zwitterionic and cationic detergent surfactants and monoethanolamine and/or other specific beta-aminoalkanols as solvents and/or buffers for improved spotting/filming and good cleaning. Some formulas do not contain large amounts of builders and are suitable for general purpose cleaning including cleaning of glass. Other formulas are concentrated and contain chelating agents (detergent builders) to improve stability of more dilute compositions prepared from the concentrated compositions. Some of the formulas, both dilute and concentrated, possess disinfectant properties.Type: GrantFiled: August 27, 1993Date of Patent: October 3, 1995Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, David C. Underwood, George E. Dostie, Paul Stiros
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Patent number: 5384063Abstract: Detergent compositions comprising a surfactant system that is either (1) a mixture nonionic and zwitterionic detergent surfactants; (2) a mixture of nonionic and amphoteric (non-zwitterionic) detergent surfactants; or (3) short chain nonionic detergent surfactant; optional hydrophobic cleaning solvent; and polycarboxylate, especially dicarboxylate, detergent builder provide superior cleaning of all of the soils commonly found in the bathroom. The compositions have a pH of from about 1 to about 5.5, preferably from about 2 to about 4 when the dicarboxylate builder is used. The compositions are in the form of aqueous liquids.Type: GrantFiled: March 19, 1993Date of Patent: January 24, 1995Assignee: The Procter & Gamble CompanyInventors: Ricky Ah-Man Woo, Michel J. Carrie, William A. Cilley, Ronald A. Masters, Daniel W. Michael, Eddy Vos
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Patent number: 5382376Abstract: Detergent compositions with excellent spotting/filming characteristics comprising propylene glycol/ethylene glycol block copolymer nonionic detergent surfactant, preferably in a surfactant mixture with a nonionic detergent surfactant having a conventional hydrocarbon hydrophobic group and a mixed propylene glycol/ethylene glycol hydrophilic group; optional hydrophobic cleaning solvent; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.Type: GrantFiled: August 17, 1993Date of Patent: January 17, 1995Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, Michael S. Maile
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Patent number: 5376298Abstract: Detergent compositions with excellent spotting/filming characteristics comprising nonionic detergent surfactant, preferably having a conventional hydrocarbon hydrophobic group and polyalkoxylate hydrophilic group; polyalkoxylate polycarboxylate surfactant/builder containing hydrocarbon hydrophobic group, polyalkoxylate moiety, and polyanionic moieties that are carboxyl groups except for one optional sulfate or sulfonate group; optional hydrophobic cleaning solvent and/or polycarboxylate detergent builder; and optional suds control system preferably comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.Type: GrantFiled: July 29, 1993Date of Patent: December 27, 1994Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5350541Abstract: Detergent compositions comprising nonionic detergent surfactant; hydrophobic cleaning solvent; and suds control system comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present.Type: GrantFiled: August 11, 1992Date of Patent: September 27, 1994Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, Michael S. Maile
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Patent number: 5342549Abstract: Detergent compositions comprising a hydrocarbyl-amidoalkyl enebetaine synthetic detergent surfactant; cleaning solvent; and buffer provide superior filming/streaking and good cleaning of hard to remove grease soils. Preferred compositions contain at least one cosurfactant. The compositions can be used to clean glass as well as for general cleaning purposes.Type: GrantFiled: June 7, 1993Date of Patent: August 30, 1994Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5336445Abstract: Aqueous, liquid hard surface detergent compositions contain beta-aminoalkanols as solvents and/or buffers for improved spotting/filming and good cleaning. Some formulas do not contain large amounts of builders and are suitable for general purpose cleaning including cleaning of glass.Type: GrantFiled: August 11, 1992Date of Patent: August 9, 1994Assignee: The Procter & Gamble CompanyInventors: Daniel W. Michael, Dennis R. Bacon
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Patent number: 5290472Abstract: Hard surface detergent compositions comprise nonionic detergent surfactant; tripropylene glycol or short chain alkyl ether of tripropylene glycol as a hydrophobic cleaning solvent; and optional, but preferred suds control system comprising fatty acid and anionic sulfonated and/or sulfated detergent surfactant. The compositions are preferably in the form of aqueous liquids and preferably have monoethanolamine and/or beta-aminoalkanol present. The compositions clean vinyl no-wax flooring without rinsing and without substantial filming/streaking.Type: GrantFiled: February 21, 1992Date of Patent: March 1, 1994Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5126061Abstract: Microcapsules which are prepared using coacervation processes and/or which have a complex structure in which there is a large central core of encapsulated material, preferably perfume, and the walls contain small wall inclusion particles of either the core material or some other material that can be activated to disrupt the wall are disclosed. The microcapsules that are prepared by coacervation and contain perfume are especially desirable for inclusion in fabric softener compositions that have a pH of about 7 or less and which contain cationic fabric softener. The encapsulated perfume preferably does not contain large amounts of relatively water-soluble ingredients. Such ingredients are added separately to the fabric softener compositions. Ingredients that have high and low volatilities as compared to, e.g., the desired perfume, can either be added to, or removed from, the perfume to achieve the desired volatility.Type: GrantFiled: July 18, 1990Date of Patent: June 30, 1992Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5112688Abstract: Microcapsules which are prepared using coacervation processes and/or which have a complex structure in which there is a large central core of encapsulated material, preferably perfume, and the walls contain small wall inclusion particles of either the core material or some other material that can be activated to disrupt the wall are disclosed. The microcapsules that are prepared by coacervation and contain perfume are especially desirable for inclusion in fabric softener compositions that have a pH of about 7 or less and which contain cationic fabric softener. The encapsulated perfume preferably does not contain large amounts of relatively water-soluble ingredients. Such ingredients are added separately to the fabric softener compositions. Ingredients that have high and low volatilities as compared to, e.g., the desired perfume, can either be added to, or removed from, the perfume to achieve the desired volatility.Type: GrantFiled: December 6, 1990Date of Patent: May 12, 1992Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 5108660Abstract: Detergent compositions comprising a hydrocarbyl-amidoalkylenesulfobetaine synthetic detergent surfactant; cleaning solvent; and buffer provide superior filming/streaking and good cleaning of both glass and hard to remove greasy/oily soils. Preferred compositions contain at least one cosurfactant. The compositions can be used to clean glass without excessive spotting/filming while being sufficiently strong to be used for general cleaning purposes.Type: GrantFiled: December 21, 1990Date of Patent: April 28, 1992Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 4961871Abstract: Powdered, abrasive, hard surface cleansers containing micro-encapsulated perfume wherein the capsules are essentially water-insoluble, but can become perfume permeable during use by the combined action of water and abrasive. The preferred capsules are formed from gelatin and a polyanionic material by coacervation techniques and then are cross-linked to provide controlled water insolubility.Type: GrantFiled: November 14, 1989Date of Patent: October 9, 1990Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael
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Patent number: 4946624Abstract: Microcapsules which are prepared using coacervation processes and/or which have a complex structure in which there is a large central core of encapsulated material, preferably perfume, and the walls contain small wall inclusion particles of either the core material or some other material that can be activated to disrupt the wall are disclosed. The microcapsules that are prepared by coacervation and contain perfume are especially desirable for inclusion in fabric softener compositions that have a pH of about 7 or less and which contain cationic fabric softener. The encapsulated perfume preferably does not contain large amounts of relatively water-soluble ingredients. Such ingredients are added separately to the fabric softener compositions. Ingredients that have high and low volatilities as compared to, e.g., the desired perfume, can either be added to, or removed from, the perfume to achieve the desired volatility.Type: GrantFiled: February 27, 1989Date of Patent: August 7, 1990Assignee: The Procter & Gamble CompanyInventor: Daniel W. Michael