Abstract: Provided are lipid nanoparticle compositions, and processes for their preparation, which are useful for the delivery of therapeutic or prophylactic agents to airway epithelium in patients.

Abstract: A component for a wearable electronic device can include a housing defining an internal volume, a first connector that is removably attachable to a head-mounted display. the first connector configured to electrically connect to the head-mounted display. and a second connector that is removably attachable to a supplemental unit. the second connector configured to electrically connect to the supplemental unit. The component can include a stiffener disposed in the internal volume, and the stiffener can be flexible along a first axis and rigid along two axes that are perpendicular to the first axis and to each other. An operational component can be disposed in the internal volume, and the operational component can be electrically connected to at least one of the first connector or the second connector.

Abstract: An apparatus for monitoring and replenishing an inventory of goods includes a first inventory area and a first movable structure having a first optical code associated with the first distinct inventory area. The first movable structure is placed in a replenishment signaling area after a supply of goods in the inventory area has been depleted. Boundary optical codes are disposed near a boundary of the replenishment signaling area. A camera generates periodic images of the replenishment signaling area and the boundary optical codes. A computer processor detects the boundary optical codes in the images and determines a boundary line of the replenishment signaling area based thereon. The processor determines a spatial relationship between the first optical code and the boundary line in the images and generates a replenishment notification based on the spatial relationship. The replenishment notification indicates that the supply of the first type of goods needs to be replenished.

Abstract: An apparatus for monitoring and replenishing an inventory of goods includes a first inventory area and a first movable structure having a first optical code associated with the first distinct inventory area. The first movable structure is placed in a replenishment signaling area after a supply of goods in the inventory area is depleted. Boundary optical codes are disposed near a boundary of the replenishment signaling area. A camera generates periodic images of the replenishment signaling area and the boundary optical codes. A computer processor detects the boundary optical codes in the images and determines a boundary line of the replenishment signaling area based thereon. The processor determines a spatial relationship between the first optical code and the boundary line in the images and generates a replenishment notification based on the spatial relationship. The replenishment notification indicates that the supply of the first type of goods needs to be replenished.

Abstract: Provided are empty lipid nanoparticle compositions, and processes for their preparation, which are useful in the preparation of therapeutic or prophylactic lipid nanoparticle compositions comprising a therapeutic or prophylactic agent including, for example, nucleic acids such as mRNA.

Abstract: A power tool comprising: a housing including a motor case and a handle portion extending along a longitudinal axis of the housing from the motor case; an electric motor having a drive shaft and mounted within the motor case; a partitioning wall extending radially between the motor case and the handle portion and forming a bearing pocket therein; a rear bearing mounted on the drive shaft and received into the bearing pocket to support the drive shaft relative to the housing; two elongate walls extending rearwardly from the partitioning wall along two sides of the handle portion; a power control module supported by the two elongate walls within the handle portion, the power control module including a circuit board having a motor drive circuit configured to drive the electric motor; and at least one cover secured to the two elongate walls to cover the circuit board.

Abstract: Various embodiments are directed to battery packs for use with surgical instruments. The battery packs may comprise a plurality of cells and at least a portion of the plurality of cells may not be electrically connected to one another. The battery packs may comprise a switch or other mechanism for interconnecting the plurality of cells and may also comprise, or be used in conjunction with, a discharge switch or plug configured to electrically connect an anode of the battery pack to a cathode of the battery pack, for example, via a resistive element.

Abstract: A compressor including a housing, a shaft configured to be rotated relative to the housing to compress a refrigerant, a motor configured to drive the shaft, a lubrication system configured to supply lubricant to the compressor, and a bearing configured to support the shaft. The shaft includes a wear-resistant sleeve-like treatment on at least a portion of an outer surface of the shaft adjacent the bearing. The lubricant is a lubricant blend composition that includes two or more lubricants, the two or more lubricants including a first lubricant and a second lubricant. The first lubricant is present at a higher volume percentage than the second lubricant, and the first lubricant includes a higher viscosity than the second lubricant.

Abstract: The present disclosure provides a method of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g. atherosclerosis, atherosclerotic cardiovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions, by orally administering to the subject an amount of a compound of formula (I) wherein A? is selected from a pharmaceutically acceptable anion, and wherein the amount administered is from about 5 mg to about 300 mg of the compound of formula (I). The present invention is also directed to pharmaceutical compositions comprising a compound of formula (I), including particular salts of a compound of formula (I), and a permeation enhancer.

Abstract: A system and method of verifying the identity of a user or registrant. The user or registrant provides identification information and registration information. The identification information may be a visual representation of an identifying item associated with location information. In some embodiments, the identification information may be a visual representation of a government issued identity. An identification module verifies the identification information and compares the verified identification information to the registration information.

Abstract: A system and method of verifying the identity of a user or registrant. The user or registrant provides identification information and registration information. The identification information may be a visual representation of an identifying item associated with location information. In some embodiments, the identification information may be a visual representation of a government issued identity. An identification module verifies the identification information and compares the verified identification information to the registration information.

Abstract: A system and method of verifying the identity of a user or registrant. The user or registrant provides identification information and registration information. The identification information may be a visual representation of an identifying item associated with location information. In some embodiments, the identification information may be a visual representation of a government issued identity. An identification module verifies the identification information and compares the verified identification information to the registration information.

Abstract: A system and method of verifying the identity of a user or registrant. The user or registrant provides identification information and registration information. The identification information may be a visual representation of an identifying item associated with location information. In some embodiments, the identification information may be a visual representation of a government issued identity. An identification module verifies the identification information and compares the verified identification information to the registration information.

Abstract: A pallet that is configured and designed to support a load of material and rest alternatively on a flat surface on a roof so as to straddle the peak or ridge of a roof. The pallets can be loaded with materials such as roofing shingles, delivered to a work site on a truck bed and lifted up and positioned on the peak or ridge of a roof without having to unload the materials from the pallets.

Abstract: A pallet that is configured and designed to support a load of material and rest alternatively on a flat surface on a roof so as to straddle the peak of ridge of a roof. The pallets can be loaded with materials such as roofing shingles, delivered to a work site on a truck bed and lifted up an positioned on the peak or ridge of a roof without having to unload the materials from the pallets.

Abstract: A pallet that is configured and designed to support a load of material and rest alternatively on a flat surface on a roof so as to straddle the peak or ridge of a roof. The pallets can be loaded with materials such as roofing shingles, delivered to a work site on a truck bed and lifted up and positioned on the peak or ridge of a roof without having to unload the materials from the pallets.

Abstract: A pallet that is configured and designed to support a load of material and rest alternatively on a flat surface on a roof so as to straddle the peak of ridge of a roof. The pallets can be loaded with materials such as roofing shingles, delivered to a work site on a truck bed and lifted up an positioned on the peak or ridge of a roof without having to unload the materials from the pallets.

Abstract: A fuel cell temperature-measuring system includes a coolant source that provides coolant at a total coolant flow rate and an initial coolant temperature. A flow field plate defines peripheral flow channels and active area flow channels through which coolant flows. The flow field plate is adapted to be positioned in a fuel cell stack between individual fuel cells. A total coolant flow provided to the common input divides into a bypass flow that flows through the peripheral flow channels and an active area flow that flows through the active area flow channels. The bypass flow combines with the active area flow to emerge from the common output with an output coolant temperature. The fuel cell temperature-measuring system includes a temperature sensor that measures the output coolant temperature from the common output. Finally, a temperature estimator estimates an active area coolant temperature from the output coolant temperature.

Abstract: A fuel cell voltage recovery system includes a fuel cell stack having a fuel cell stack voltage between fuel cell stack terminals which is at a first voltage during normal fuel cell operation. The system also includes a high voltage electrical system operating at a first DC operating voltage that is generally higher than the first voltage of the fuel cell stack. A boost converter in electrical connection with the fuel cell stack and the high voltage electrical system operates in a normal control mode to transfer electrical power from the fuel cell stack to the high voltage electrical system through regulation and control of average stack output current (boost input current) during normal fuel cell operation. The boost converter can also operate in a voltage control mode to lower the fuel cell stack voltage to a second voltage that is lower than the first voltage. A FCS controller controls the operation of the boost converter.