Abstract: A torque transmitting device for a drivetrain for transmitting a drive torque to an output element. The device having: an electric motor with a conversion unit, which comprises a stator and a rotor that is rotatable relative to the stator, for converting electrical energy into mechanical energy; and a torsional vibration damper with a damper mass received on a damper mass support such that the damper mass can be deflected to a limited extent against the action of a restoring force, the damper mass being arranged so as to overlap radially with the conversion unit.

Abstract: A method for adapting driving behavior includes inspecting driving behavior of a motor vehicle (1) travelling consecutively with a road user (2). Consecutive travel is detected by at least one sensor of the motor vehicle (1). If the other road user (2) is not detected, the method uses traffic data to predict a position of the other road user (2). If the predicted position of the road user (2) reveals consecutive travel, the method inspects the driving behavior of the motor vehicle (1) as in the case of consecutive travel detected by the at least one sensor. The method adapts a driving behavior while using few sensors to provide a high level of road safety and/or a high level of driving comfort. Optionally, a human-machine interface may display or report back a virtual representation of the road user in the predicted position to the driver of the motor vehicle.

Abstract: The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.

Abstract: Methods of treating a tumor in a subject are provided herein. In exemplary embodiments, the method comprises measuring the expression level of MGMT, GPRASP1, CHGA, MAPK8, ATP6V0A2, or FGF7, or any combination thereof, in a sample comprising a cell or cells from the tumor, and administering to the subject an alkylating chemotherapy, radiation therapy, or a combination comprising alkylating chemotherapy and radiation therapy, depending on the expression level(s). Related methods, kits, systems, computer-readable storage media, and methods implemented by a processor in a computer are further provided herein.

Abstract: Biomarker signatures were identified which can be used to diagnose or predict kidney or liver toxicity and more specifically renal tubular toxicity as a consequence of disease or drug treatment.

Abstract: The present invention is directed, in part, to a method of measuring ?-2-microglobulin to assess glomerular alteration or damage of the kidney.

Abstract: Biomarker signatures were identified which can be used to diagnose or predict kidney or liver toxicity and more specifically renal tubular toxicity as a consequence of disease or drug treatment.