Abstract: The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/target of rapamycin complex (TORC) inhibitor combination therapies, and compositions and methods comprising biomarker genes for identifying subjects that will respond to MEK inhibitor/chemotherapy combination therapies.

Abstract: The present disclosure provides a method for determining a genotype of one or more biomarker genes in a tumor sample of a subject afflicted with cancer, the method comprising determining a genotype of one or more biomarker genes in the tumor sample and classifying a subject as sensitive or resistant to a therapy comprising a SHP2 inhibitor based on the genotype the one or more biomarker genes in the tumor sample.

Abstract: In one aspect, the present disclosure provides a monolithic percutaneous-screw system for use in spinal surgery. The system includes (i) a receiver having a distal base and a pair of opposing arms extending proximally from the base, a pair of opposing distal breakoff sections, each connected monolithically to a proximal end of a corresponding one of the arms, (ii) a pair of opposing proximal breakoff sections, (iii) a pair of opposing intermediate extenders, each extending from a distal end, connected monolithically to a corresponding one of the distal breakoff sections, to a proximal end connected monolithically to a corresponding one of the proximal breakoff section, and (iv) a guide cap connected monolithically to both of the proximal breakoff sections.

Abstract: A cart retention system for a multi-cart bay can include a first retainer configured to retain a front cart in the multi-cart bay and a second retainer configured to retain a rear cart in the multi-cart bay such that the rear cart is held spaced from the front cart. The system can also include a third retainer configured to retain both the front cart and the rear cart in the multi-cart bay separate from each other.

Abstract: A multiple-cap-remover for removing and holding spinal-implant guide caps, including a chamber component and a plunger movable disposed within the chamber. The chamber component has a chamber wall extending to an open end, and a cap-retaining component extending radially inward from an inner surface of the chamber at or adjacent the distal end. The distal opening is sized and shaped to allow the guide caps to pass through the opening and into the chamber component. The chamber component is sized and shaped to receive, one at a time, and hold simultaneously, multiple caps removed from respective spinal-implant assemblies using the instrument. The instrument may further have a sliding component connected movably to a body and connected to the plunger such that, when moved distally, it moves the plunger to push the caps captured beyond the cap-retaining component and out of the chamber component via the opening.

Abstract: In one aspect, the present disclosure provides a monolithic percutaneous-screw system for use in spinal surgery. The system includes (i) a receiver having a distal base and a pair of opposing arms extending proximally from the base, a pair of opposing distal breakoff sections, each connected monolithically to a proximal end of a corresponding one of the arms, (ii) a pair of opposing proximal breakoff sections, (iii) a pair of opposing intermediate extenders, each extending from a distal end, connected monolithically to a corresponding one of the distal breakoff sections, to a proximal end connected monolithically to a corresponding one of the proximal breakoff section, and (iv) a guide cap connected monolithically to both of the proximal breakoff sections.

Abstract: The present disclosure relates to a pharmaceutical composition of a combination of tramadol-etoricoxib hydrochloride for the treatment of pain. The production method of the pharmaceutical composition is based on two active ingredients including granules and/or multi-particulates containing tramadol hydrochloride and granules and/or multi-particulates containing etoricoxib. The pharmaceutical composition can be contained in a mixture of powders, included in a two-layer tablet with or without a coating, or in a capsule as granulates and/or tablets with or without a coating.

Abstract: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.

Abstract: A gauge is provided for measuring the thickness of roofing shingles and vinyl siding. The gauge includes a main body having at least two elongated slots, one slot functioning to receive and measure the thickness of roofing shingles and the other slot functioning to receive and measure the thickness of vinyl siding. Both slots are open from a respective edge of the main body and include a width that progressively decreases from the open edge to a terminating point in the slot.

Abstract: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.

Abstract: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.

Abstract: A gauge is provided for measuring the thickness of roofing shingles and vinyl siding. The gauge includes a main body having at least two elongated slots, one slot functioning to receive and measure the thickness of roofing shingles and the other slot functioning to receive and measure the thickness of vinyl siding. Both slots are open from a respective edge of the main body and include a width that progressively decreases from the open edge to a terminating point in the slot.

Abstract: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.

Abstract: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the differential display of protein samples from multiple cell types. The present invention thus provides improved methods for the analysis of multiple samples containing large numbers of proteins.

Abstract: A pneumatic fastener includes a housing and a handle coupled to the housing. The handle defines an inlet channel for delivering compressed gas to the housing. A trigger valve is in communication with the inlet channel and configured to actuate the pneumatic fastener. A fastener driving assembly is disposed within the housing. The fastener driving assembly includes a cylinder and a piston that reciprocates within the cylinder to drive a fastener. A valve piston is coupled to the fastener driving assembly. Actuation of the valve piston causes compressed air to drive the piston within the cylinder to drive the fastener. An outer cap is coupled to the housing and an inner cap is disposed at least partially within the outer cap. The inner cap includes an opening in communication with the trigger valve for porting the compressed air to a region above the valve piston.

Abstract: A belt sander is disclosed that may include a sanding assembly having a first roller and a second roller, the sanding assembly being configured to receive a sanding belt around the first roller and the second roller to define a sanding surface therebetweeen. The belt sander may include a motor operationally coupled to the sanding assembly and opposite the sanding surface, the motor being configured to rotate at least the first roller and thereby rotate the sanding belt around the first roller and the second roller, as well as a handgrip formed around at least a portion of the motor and substantially encasing the motor.

Abstract: A belt sander is disclosed that may include a sanding assembly having a first roller and a second roller, the sanding assembly being configured to receive a sanding belt around the first roller and the second roller to define a sanding surface therebetweeen. The belt sander may include a motor operationally coupled to the sanding assembly and opposite the sanding surface, the motor being configured to rotate at least the first roller and thereby rotate the sanding belt around the first roller and the second roller, as well as a handgrip formed around at least a portion of the motor and substantially encasing the motor.

Abstract: A belt sander is disclosed that may include a sanding assembly having a first roller and a second roller, the sanding assembly being configured to receive a sanding belt around the first roller and the second roller to define a sanding surface therebetween. The belt sander may include a motor operationally coupled to the sanding assembly and opposite the sanding surface, the motor being configured to rotate at least the first roller and thereby rotate the sanding belt around the first roller and the second roller, as well as a handgrip formed around at least a portion of the motor and substantially encasing the motor.

Abstract: A belt sander is disclosed that may include a sanding assembly having a first roller and a second roller, the sanding assembly being configured to receive a sanding belt around the first roller and the second roller to define a sanding surface therebetweeen. The belt sander may include a motor operationally coupled to the sanding assembly and opposite the sanding surface, the motor being configured to rotate at least the first roller and thereby rotate the sanding belt around the first roller and the second roller, as well as a handgrip formed around at least a portion of the motor and substantially encasing the motor.

Abstract: A belt sander is disclosed that may include a sanding assembly having a first roller and a second roller, the sanding assembly being configured to receive a sanding belt around the first roller and the second roller to define a sanding surface therebetweeen. The belt sander may include a motor operationally coupled to the sanding assembly and opposite the sanding surface, the motor being configured to rotate at least the first roller and thereby rotate the sanding belt around the first roller and the second roller, as well as a handgrip formed around at least a portion of the motor and substantially encasing the motor.