Abstract: Described herein are i) sequestering agents and ii) central nervous system (CNS) active agents for the treatment of intoxication due to toxic agents such as drugs of abuse, and associated symptoms. Also disclosed herein, are a cucurbituril and naloxone for use in the treatment of opioid overdoses through sequestering and excretion of the bound molecule of interest through the urine. Also provided herein, are kits and methods of treatment of the disclosure.

Abstract: A system for locating a wireless device involves the use of the measured signal strength of various base stations in the building or outdoor area under analysis. A topological map of the building or outdoor area under analysis is created. The map is divided into cells, and signal intensities are collected in each cell. For each cell, the signal from a particular base station is fit to a statistical distribution, such as a Gaussian distribution, and the parameters of the statistical distribution are estimated. After a device obtains a set of signal strength measurements, a probabilistic technique is employed to estimate the probability of the existence of the measurements in each of the cells of the building or area under analysis. The estimated location is the cell with the highest probability. A mobile user is tracked with the use of a Markov chain and the system can be calibrated to account for equipment and environmental variations.

Abstract: The present invention relates generally to the field of computing in resource-poor environments, such as mobile and/or wireless computing systems, and, more particularly, to a system and a method for adaptation-aware editing and/or progressive update propagation that enable authoring multimedia content and/or collaborative work on mobile and/or wireless computing systems and devices. A method for the exchange of a data document between a central data store and a client, the data document including one or more data elements, may be provided. The method may comprise transmitting the data document from the central data store to the client, wherein the transmitted data document received at the client includes data elements having a lower fidelity level as compared with the fidelity level of the data elements stored in the version of the data document at the data store, and modifying one or more data elements of the data document at the client.

Abstract: A component-based adaptation system is provided in which the operation of an application or the data being used by the application is adapted according to an application-specific or a user-specific policy. Following a request for a document by an application, the requested document is retrieved and converted into an application-independent format. The data of the document is then supplied to the application according to a user-specific or application-specific policy. The application of the policy may result in a lower fidelity version or a subset of the data of the requested document being supplied to the application. The policy may also govern the updating of the data supplied to the application. The data supplied to the application may be updated following the occurrence of a tracked event in the application or according to a background policy governing the supply of updated data without reference to the user's operation of the application.

Abstract: Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by hydroxy, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.

Abstract: Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionally acylated and/or aliphatically substituted amino or by an aza-, diaza-, azoxa- or oxa-cycloaliphatic radical, or is an oxacycloaliphatic hydrocarbon radical bonded via a carbon atom, or is an optionally aliphatically N-substituted or N-acylated azacycloaliphatic hydrocarbon radical, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.