Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.

Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

Abstract: An improved antenna for microwave ablation uses a triaxial design which reduces reflected energy allowing higher power ablation and/or a smaller diameter feeder line to the antenna.

Abstract: A medical instrument or device used to decrease blood loss during surgery and/or other medical procedures. The device includes a microwave antenna housed in a handset (or laparoscopic probe) that is placed in close proximity to the tissue of interest. The device runs in the microwave spectrum and receives power from a from a microwave generator. When turned on (triggered), the device delivers microwave energy to tissue, providing a cutting or cautery effect.

Abstract: A method and system delivers microwave energy to a vessel, such as a vein for the treatment of varicose veins, in a controllable heating pattern and to provide relatively fast heating and ablation of the vessel. The method and system comprises a microwave delivery device for heating the vessel, and a microwave power source for supplying microwave power to the delivery device. The method and system may also include a cooling system, a temperature monitoring, feedback and control system, an ultrasound or other imaging device, and/or a device for assuring generally uniform energy delivery in the vessel.

Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

Abstract: A microscope probe including a coaxial tip and a coplanar waveguide (CPW) formed on a silicon substrate is provided. The coaxial tip includes a tip shaft and a tip nib formed from the silicon substrate with the tip nib extending from the tip shaft opposite the silicon substrate. The tip shaft includes a first layer of a first conductive material formed over the silicon substrate, a second layer of an insulating material formed over the first layer, and a third layer of a second conductive material formed over the second layer. The tip nib includes the first layer of the first conductive material formed over the silicon substrate and exposed from the second layer and the third layer of the tip shaft. The CPW includes a center conductor formed from the first layer of the first conductive material and a first and a second outer conductor formed from the second layer of the second conductive material.

Abstract: Using pulsed or continuous-wave sources, broadband electromagnetic energy generally in the 10 MHz to 300 GHz range is applied through one or a plurality of near-field antennas such as coaxial probe tips. The electromagnetic energy reflected from the surface or transmitted through the near surface of the object (e.g. surface of skin or other tissue or cells) is detected, and the ratio of the test measurement to that from normal tissue is recorded and presented to determine the degree of dielectric contrast, hence inhomogeneity. This degree of contrast is used both on its own and in conjunction with simultaneously acquired optical images to map the boundary of an organ inhomogeneity such as a tumor. The bundle of antennas may be scanned over a surface of the object on a pixel-by-pixel basis to determine the spectra of the sample on a pixel-by-pixel basis, allowing a two dimensional display of the absorption spectra to be provided.

Abstract: A near-field antenna structure is described that is an effective delivery tool for radiofrequency (RF) and microwave power to achieve coagulative necrosis in metastatic tumors while reducing or eliminating thermal conduction along the structure. This tool is a probe small enough to be used safely virtually anywhere in the neck, chest, abdomen, and pelvis, and be guided by computerized tomography (CT) or ultrasonic imaging.

Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

Abstract: A microscope probe including a coaxial tip and a coplanar waveguide (CPW) formed on a silicon substrate is provided. The coaxial tip includes a tip shaft and a tip nib formed from the silicon substrate with the tip nib extending from the tip shaft opposite the silicon substrate. The tip shaft includes a first layer of a first conductive material formed over the silicon substrate, a second layer of an insulating material formed over the first layer, and a third layer of a second conductive material formed over the second layer. The tip nib includes the first layer of the first conductive material formed over the silicon substrate and exposed from the second layer and the third layer of the tip shaft. The CPW includes a center conductor formed from the first layer of the first conductive material and a first and a second outer conductor formed from the second layer of the second conductive material.

Abstract: A method and device delivers microwave power to an antenna through a coaxial cable utilizing air or other gases as its dielectric core. The cable includes supports made of low-loss materials to keep the inner conductor centered in the cable, and defining spaces therebetween for the air or gas. Channels in the supports allow the air or gas to circulate in the cable. The gas may be chilled or cooled to provide an addition level of heat dissipation. The device enables delivery of large amounts of power to tissue without undue heating of the feed cable or peripheral tissues, and without increasing the diameter of the feeding cable or antenna, keeping the antenna safe for percutaneous use.

Abstract: A digital-to-analog converter supporting high speed operation is defined. The converter includes a plurality of sampler circuits in electrical communication with a digital signal source and a summation circuit in electrical communication with the plurality of sampler circuits. A sampler circuit of the plurality of sampler circuits is adapted to sample a bit of a plurality of bits from the digital signal source with a half-sinusoidal signal forming a sampled signal. The sampler may include a plurality of diodes and a sinusoidal signal source. The sinusoidal signal source toggles the plurality of diodes on and off thereby forming the sampled signal at a sampler output port. The summation circuit is adapted to combine the sampled signal from each of the plurality of sampler circuits to form an analog signal portion representative of the plurality of bits. Exemplary summation circuits include an R-2R resistance ladder and a Wilkinson power combiner.

Abstract: A digital-to-analog converter supporting high speed operation is defined. The converter includes a plurality of sampler circuits in electrical communication with a digital signal source and a summation circuit in electrical communication with the plurality of sampler circuits. A sampler circuit of the plurality of sampler circuits is adapted to sample a bit of a plurality of bits from the digital signal source with a half-sinusoidal signal forming a sampled signal. The sampler may include a plurality of diodes and a sinusoidal signal source. The sinusoidal signal source toggles the plurality of diodes on and off thereby forming the sampled signal at a sampler output port. The summation circuit is adapted to combine the sampled signal from each of the plurality of sampler circuits to form an analog signal portion representative of the plurality of bits. Exemplary summation circuits include an R-2R resistance ladder and a Wilkinson power combiner.

Abstract: A method and device delivers microwave power to an antenna through a coaxial cable utilizing air or other gases as its dielectric core. The cable includes supports made of low-loss materials to keep the inner conductor centered in the cable, and defining spaces therebetween for the air or gas. Channels in the supports allow the air or gas to circulate in the cable. The gas may be chilled or cooled to provide an addition level of heat dissipation. The device enables delivery of large amounts of power to tissue without undue heating of the feed cable or peripheral tissues, and without increasing the diameter of the feeding cable or antenna, keeping the antenna safe for percutaneous use.

Abstract: Using pulsed or continuous-wave sources, broadband electromagnetic energy generally in the 10 MHz to 300 GHz range is applied through one or a plurality of near-field antennas such as coaxial probe tips. The electromagnetic energy reflected from the surface or transmitted through the near surface of the object (e.g. surface of skin or other tissue or cells) is detected, and the ratio of the test measurement to that from normal tissue is recorded and presented to determine the degree of dielectric contrast, hence inhomogeneity. This degree of contrast is used both on its own and in conjunction with simultaneously acquired optical images to map the boundary of an organ inhomogeneity such as a tumor. The bundle of antennas may be scanned over a surface of the object on a pixel-by-pixel basis to determine the spectra of the sample on a pixel-by-pixel basis, allowing a two dimensional display of the absorption spectra to be provided.

Abstract: A combined near-zone electromagnetic field and topography probe based on a scanning-probe microscope (SPM). One or a plurality of sub-wavelength electromagnetic antennas and waveguides are integrated with tip-cantilever assemblies commonly used in scanning probe microscopy, combining the contact- or non-contact-mode tip-sample distance control and topography-sensing capacity of the SPM with the ability to measure or excite local electromagnetic fields on the sample. A wide range of topography-sensing forces acting on the tip-cantilever assembly can be employed, such as capillary, van der Waals, electrostatic and magnetic. Simultaneous measurement and/or excitation of electromagnetic fields in the frequency range from near zero to tens of THz can be performed, limited only by the design and ability of the antenna and waveguide material(s) to localize and guide the electromagnetic energy, and by suitable means for energy detection and/or generation connected to the waveguide.