Abstract: A system and a computer-implemented method for identifying a region of interest for image registration is provided. The method includes analyzing three-dimensional CT or MRI image data of a tissue to identify one or more structural elements therein and determining a spatial arrangement of the structural elements, accessing first ultrasound image data of the tissue and performing a first image registration of the first ultrasound image data with the CT or MRI image data at a first accuracy, and identifying, based on the spatial arrangement of the structural elements, a region of interest for a subsequent second image registration of second ultrasound image data of the tissue with the CT or MRI image data at a second accuracy that is higher than the first accuracy.

Abstract: In some examples, an electronic device comprises a processor and a power circuit coupled to the processor. The power circuit is to provide power to the processor and to measure a current drawn from the power circuit by the processor. The electronic device also comprises a voltage regulator controller coupled to the processor and the power circuit. The voltage regulator controller is to receive a current usage prediction from the processor, receive the measurement from the power circuit, compare the current usage prediction and the measurement, and, based on the comparison, drive the power circuit in accordance with the measurement instead of the current usage prediction.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Bias scores can be generated from articles. A bias score generator can be configured to aggregate and process articles to identify entities and policies that appear in the articles and to generate sentiment values for the entities and policies. Aspect-based targeted sentiment analysis may be employed to generate the sentiment values. The bias score generator can process the sentiment values to generate a bias score for each article. Bias scores for multiple articles can be combined to generate a media bias score for a source of the articles. Bias loaded words and bias loaded snippets may also be used to generate a media bias score.

Abstract: The present invention relates to an aircraft galley, and a method and apparatus for configuring the same. The aircraft galley includes: a frame attached to walls of a cabin of an aircraft in a horizontal direction and has an open accommodating space; one or more first to third cabinet assemblies all detachably connected to the frame, wherein the sizes of the first to third cabinet assemblies and the accommodating space are in a predetermined proportion to each other, such that the space can be filled with different combinations formed by at least two of the first to third cabinet assemblies, and the different combinations differ in at least one of: types of cabinet assemblies, the number of each type of the cabinet assemblies, and the arranged position of each cabinet assembly. Therefore, the technical effects of improving the utilization efficiency of the aircraft galley and reducing airline costs are achieved.

Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5?-monophosphate-activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

Abstract: A technique may include receiving, by a management service a plurality of instance configurations from a client device. The technique may then include receiving, by the management service, information identifying a launch request for a compute instance. The technique may include determining, by the management service, one or more candidate shapes for the compute instance based at least in part on the plurality of instance configurations. The technique may include selecting, by the management service and from the one or more candidate shapes, a launch shape for the compute instance and launching the compute instance using the launch shape. The technique may then include providing, the client device access to the compute instance, launched based on the launch shape.

Abstract: An attachment for a hair styling apparatus, the attachment comprising an annular duct having an air inlet for receiving an airflow from a hair styling apparatus, and at least one vane located within the duct for directing the airflow from the air inlet towards an air outlet.

Abstract: Machine learning automatic pipeline management for automated software deployment is described. An adjustment to computing capacity for a region of a multi-region computing network is identified. A service to be deployed in the region of the multi-region computing network is further identified. Configuration settings for deployment of the service in the region is generated using past deployment data for the service in other regions of the multi-region computing network. A continuous code delivery service is directed to add a stage to a software deployment pipeline for the region. The stage may be configured using the at least one configuration setting.

Abstract: A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles.

Abstract: Known infrared radiators have a moulded body, which has a radiation surface that emits short-wave or medium-wave infrared radiation with a first peak emission wavelength. In order to provide, proceeding therefrom, an infrared radiator with an emissions spectrum which is well matched to absorption characteristics with a maximum around 2750 nm, and which furthermore can be operated with a high electrical power density, and with which the warming-up time in industrial applications, such as, for example, drying of inks, joining of plastics or bending of glass, can be shortened, according to the invention a radiation converter material is applied to at least a part of the radiation surface and, as a consequence of heating by the infrared radiation of the first peak emission wavelength, emits infrared radiation with a second peak emission wavelength which is of a longer wavelength than the first peak emission wavelength.

Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: In some aspects of the present disclosure, a method includes performing an atomic layer deposition (ALD) process to form an antimony-containing coating of a surface of a substrate. The ALD process includes providing a first reactant to the surface of the substrate. The first reactant adsorbs onto the surface to form an adsorption layer thereon. The ALD process further includes providing a second reactant to the surface of the substrate. The second reactant includes a reducing agent. The second reactant reacts with the adsorption layer to form a layer of the antimony-containing coating. The ALD process further includes repeating the providing of the first reactant and the providing of the second reactant one or more times to form the antimony-containing coating.

Abstract: A method used in forming an array of capacitors comprises forming a stack comprising sacrificial material and insulative material that is between a top and a bottom of the sacrificial material. The insulative material at least predominately comprises at least one of a silicon nitride, a silicon boronitride, and a silicon carbonitride. Horizontally-spaced openings are formed partially through the sacrificial material. A lining is deposited within the horizontally-spaced openings and directly above the sacrificial material. After depositing the lining, the horizontally-spaced openings are extended through remaining of the sacrificial material. The extended horizontally-spaced openings extend through the insulative material. The insulative material with extended horizontally-spaced openings there-through comprises an insulative horizontal lattice.

Abstract: A computing system including a processor configured to receive atomistic molecular dynamics simulation data of training-time conformers of an atomistic structure of a molecule. The processor is further configured to compute coarse-grained molecular dynamics simulation data based at least in part on the atomistic molecular dynamics simulation data. The coarse-grained molecular dynamics simulation data is computed at least in part by converting the atomistic structure into a coarse-grained structure. The processor is further configured to train a denoising diffusion model using the coarse-grained molecular dynamics simulation data. At the denoising diffusion model, the processor is further configured to receive a runtime conformer of the coarse-grained structure and generate a coarse-grained force field estimate associated with the runtime conformer.

Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.