Abstract: Availability zone and region recovery are described. For an availability zone (AZ), a recovery availability zone (rAZ) may be identified based on available computing capacity of the recovery availability zone and geographic proximity of the availability zone relative to the recovery availability zone. In an instance in which the availability zone is impacted in which at least one of hardware and software of the availability zone is not fully operational, a virtual private cloud (VPC) is generated that establishes a peered connection between the availability zone and the recovery availability zone. A service is executed in the recovery availability zone, permitting any other services executing in the availability zone to invoke the service and become partially or fully operational.

Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of autoimmune disease or cancer.

Abstract: A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR.

Abstract: In variants, a method for analog product determination can include: determining functional property feature values for a target and determining variable values for a prototype based on the functional property feature values for the target.

Abstract: A method of predicting occupancy of unseen areas in a region of interest (ROI) includes obtaining a depth image of the ROI, the depth image being captured from a first height; generating an occupancy map based on the obtained depth image, the occupancy map comprising an array of cells corresponding to locations in the ROI; and generating an inpainted map by inputting the occupancy map into a trained inpainting network, the inpainted map comprising an array of cells corresponding to the ROI, and wherein the inpainting network is trained by comparing an output of the inpainting network, based on inputting a training depth image taken from the first height, to a ground truth map, the ground truth map being based on a combination of the training depth image and a depth image taken at a height different than the first height.

Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: In variants, the method for determining a sample recommendation can include: determining characteristic values for a sample, determining target characteristic values, determining a similarity score for the sample based on the characteristic values for the sample and the target characteristic values, training a prediction model, and determining a sample recommendation.

Abstract: The method for protein selection can include: characterizing a protein set, training a prediction model, determining target characteristic values, and determining a candidate protein set based on the target characteristic values.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: The present invention relates to a method for the design and manufacture of a dental component with a surface, wherein a 3D model of the dental component is designed by means of a CAD unit and the dental component is manufactured by a CAM unit on the basis of the 3D model.

Abstract: The current invention relates to a peritoneal dialysis filter device, which comprises a housing comprising a first port and a second port, and a hollow fibre membrane formed from hollow hydrophilic fibres within the housing. When in use, a dialysate from a subject enters the filter device through the first port and exits via the second port in an outflow direction, and a regenerated dialysate from a sorbent system enters the filter device through the second port and exits via the first port in an inflow direction. Also disclosed herein is a peritoneal dialysis system comprising said filter device, a method for controlling dialysate flow in a peritoneal dialysis system, and a haemodialysis device.

Abstract: Provided is an air diffuser and a construction method thereof. The air diffuser is especially applied to the field of civil aircrafts. The air diffuser comprises: an open upper end part; an open lower end part; and an air flow passage defined between the open upper end part and the open lower end part, the air flow passage comprising a first side wall and a second side wall which are connected between the open upper end part and the open lower end part and are symmetrically located with respect to a vertical center plane of the air diffuser; wherein the section outline of each of the first side wall and the second side wall has a curved shape bending inwards, such that in a direction from the open upper end part to the open lower end part, the air flow passage has, in sequence, a contraction portion bending toward the vertical center plane and an expansion portion away from the vertical center plane.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A system including an assembly arranged in at least one of a seat and a steering wheel of a vehicle and a measurement circuit. The assembly includes a sensor and a heater arranged adjacent to the sensor. The measurement circuit is configured to output an excitation signal to the measurement circuit and the assembly and measure a resonant frequency of the measurement circuit and the assembly in response to the excitation signal. The measurement circuit is configured to determine a capacitance value based on the resonant frequency and determine whether a body part is in proximity to the sensor based on the capacitance value.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: A method for sensing a cutting-edge load in a motor-driven machine-tool unit having a stator unit and a rotor unit that is rotatable at least about an axis of rotation. The rotor unit includes a tool receiving unit that is adjustable along the axis of rotation and to which a clamping force can be applied, for fixing and clamping a releasably fixable tool shank of a tool. A tool head of the tool includes at least one individual cutting edge. A tool sensor is provided for sensing the load on the tool, the tool sensor being realized as an individual-cutting-edge sensor for sensing a cutting-edge load on the individual cutting edge.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.