Abstract: Described herein are compounds of Formula I: I and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R7, RF, t1, Y1, and Y2 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: Disclosed herein is a material for use in sorbent-based dialysis, the material comprising: acidic and/or neutral cation exchange particles; alkaline anion exchange particles; and one or more of an alkali metal carbonate, a water insoluble alkaline earth metal carbonate, and a water insoluble polymeric ammonium carbonate. Also disclosed herein are uses of said material and its preparation.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present invention relates to an aircraft galley, and a method and apparatus for configuring the same. The aircraft galley includes: a frame attached to walls of a cabin of an aircraft in a horizontal direction and has an open accommodating space; one or more first to third cabinet assemblies all detachably connected to the frame, wherein the sizes of the first to third cabinet assemblies and the accommodating space are in a predetermined proportion to each other, such that the space can be filled with different combinations formed by at least two of the first to third cabinet assemblies, and the different combinations differ in at least one of: types of cabinet assemblies, the number of each type of the cabinet assemblies, and the arranged position of each cabinet assembly. Therefore, the technical effects of improving the utilization efficiency of the aircraft galley and reducing airline costs are achieved.

Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5?-monophosphate-activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

Abstract: In some aspects of the present disclosure, a method includes performing an atomic layer deposition (ALD) process to form an antimony-containing coating of a surface of a substrate. The ALD process includes providing a first reactant to the surface of the substrate. The first reactant adsorbs onto the surface to form an adsorption layer thereon. The ALD process further includes providing a second reactant to the surface of the substrate. The second reactant includes a reducing agent. The second reactant reacts with the adsorption layer to form a layer of the antimony-containing coating. The ALD process further includes repeating the providing of the first reactant and the providing of the second reactant one or more times to form the antimony-containing coating.

Abstract: A method for sensing a cutting-edge load in a motor-driven machine-tool unit having a stator unit and a rotor unit that is rotatable at least about an axis of rotation. The rotor unit includes a tool receiving unit that is adjustable along the axis of rotation and to which a clamping force can be applied, for fixing and clamping a releasably fixable tool shank of a tool. A tool head of the tool includes at least one individual cutting edge. A tool sensor is provided for sensing the load on the tool, the tool sensor being realized as an individual-cutting-edge sensor for sensing a cutting-edge load on the individual cutting edge.

Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: The present invention relates to a method for the design and manufacture of a dental component with a surface, wherein a 3D model of the dental component is designed by means of a CAD unit and the dental component is manufactured by a CAM unit on the basis of the 3D model.

Abstract: The current invention relates to a peritoneal dialysis filter device, which comprises a housing comprising a first port and a second port, and a hollow fibre membrane formed from hollow hydrophilic fibres within the housing. When in use, a dialysate from a subject enters the filter device through the first port and exits via the second port in an outflow direction, and a regenerated dialysate from a sorbent system enters the filter device through the second port and exits via the first port in an inflow direction. Also disclosed herein is a peritoneal dialysis system comprising said filter device, a method for controlling dialysate flow in a peritoneal dialysis system, and a haemodialysis device.

Abstract: Provided is an air diffuser and a construction method thereof. The air diffuser is especially applied to the field of civil aircrafts. The air diffuser comprises: an open upper end part; an open lower end part; and an air flow passage defined between the open upper end part and the open lower end part, the air flow passage comprising a first side wall and a second side wall which are connected between the open upper end part and the open lower end part and are symmetrically located with respect to a vertical center plane of the air diffuser; wherein the section outline of each of the first side wall and the second side wall has a curved shape bending inwards, such that in a direction from the open upper end part to the open lower end part, the air flow passage has, in sequence, a contraction portion bending toward the vertical center plane and an expansion portion away from the vertical center plane.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A system including an assembly arranged in at least one of a seat and a steering wheel of a vehicle and a measurement circuit. The assembly includes a sensor and a heater arranged adjacent to the sensor. The measurement circuit is configured to output an excitation signal to the measurement circuit and the assembly and measure a resonant frequency of the measurement circuit and the assembly in response to the excitation signal. The measurement circuit is configured to determine a capacitance value based on the resonant frequency and determine whether a body part is in proximity to the sensor based on the capacitance value.

Abstract: An inflatable partition includes a flexible membrane, an inflatable frame, and a support member coupled to the inflatable frame. The inflatable frame extends along a periphery of the flexible membrane and has an inner edge adjacent to the flexible membrane and an outer edge. The inflatable frame further includes a sealing mechanism extending along at least a portion of the outer edge and the inflatable frame is inflatable between a first state and a second state. The inflatable partition includes a first structural member and a second structural member. Each of the first and second structural members is coupled to the inflatable frame and extends vertically from the upper portion to the bottom portion of the inflatable frame and the first and second structural members define an opening in the inflatable partition.

Abstract: A method for sensing a cutting-edge load in a motor-driven machine-tool unit having a stator unit and a rotor unit that is rotatable at least about an axis of rotation. The rotor unit includes a tool receiving unit that is adjustable along the axis of rotation and to which a clamping force can be applied, for fixing and clamping a releasably fixable tool shank of a tool. A tool head of the tool includes at least one individual cutting edge. A tool sensor is provided for sensing the load on the tool, the tool sensor being realized as an individual-cutting-edge sensor for sensing a cutting-edge load on the individual cutting edge.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.