Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: Systems and methods disclosed herein provide an improved high voltage plasma-based product treatment by integrating the plasma reactor into the processing container. This unique device can deliver a high throughput rate of raw food, without adverse effects on quality. The system is operationally efficient, and is capable of being scaled up or down to provide lower or higher throughput rates, depending on the product manufacturer or processor's needs. In particular, the system obviates the need for further containerization or packaging of product during pasteurization processing.

Abstract: An electric device includes a housing, an electromechanical assembly housed within the housing, a battery arranged within the housing and comprising at least one tabless battery cell, and at least one connector that is electrically coupled to the electromechanical assembly and the battery so as to electrically connect the electromechanical assembly and the battery. The at least one connector is mechanically decoupled from at least one of the electromechanical assembly and the battery.

Abstract: An abrasive apparatus includes a backing pad comprising a filler material having a variable stiffness material configured with a first stiffness when the abrasive apparatus is in a non-working state, and a second stiffness that is higher than the first stiffness when the abrasive apparatus is in a working state. In addition, the abrasive apparatus includes an abrasive surface connected to the backing pad.

Abstract: An impact tool includes a controller configured to control power being delivered to the and operable in one of: (a) a normal mode where the controller allows power to be delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a normal transition torque; and (b) a control mode where the controller controls power being delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a control transition torque that is greater than the normal transition torque.

Abstract: An anchoring tool includes a driving member defining a striking axis and a driving actuator configured to actuate the driving member along the striking axis to drive a first fastener into a workpiece. The anchoring tool further includes a bending mechanism having a first deforming member configured to deform the first fastener at least partially out of the striking axis.

Abstract: A fastener includes an elongated body having a striking end, a middle region, and a tip end region. The striking end and the middle region define a longitudinal axis. The striking end has a first cross-section that is substantially equivalent to a second cross-section of the middle region, and the tip end region includes a tip that is offset relative to the longitudinal axis.

Abstract: A computer implemented method includes collecting multi-modal residential real estate data from networked machines. The multi-modal residential real estate data is segregated into relational data, textual data and image data to form segregated data. Statistical anomalies in the segregated data are corrected to form first refined data. The first refined data is augmented to reduce sparsity and form second refined data. Numerical embedding vectors are computed from the second refined data. The numerical embedding vectors are aggregated by geographic region. A deep neural network is trained using the numerical embedding vectors to form models for predicting residential real estate attributes. The models are utilized to compute a dynamic value for a specified residential real estate asset. Parcels in a geographic area surrounding the specified residential real estate asset are defined. The models compute dynamic values for the parcels in the geographic area.

Abstract: A compressed air storage device has a flexible, elongated tubular configuration in which the tube has an internal volume that is configured to store sufficient compressed air to drive a hand-held pneumatic tool. The compressed air storage device has a variable diameter along its length and an internal space that extends between and communicates with couplings disposed at opposed ends of the device.

Abstract: An impact tool includes a controller configured to control power being delivered to the and operable in one of: (a) a normal mode where the controller allows power to be delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a normal transition torque; and (b) a control mode where the controller controls power being delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a control transition torque that is greater than the normal transition torque.

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: The present disclosure provides methods and compositions for the treatment of pneumonitis (including checkpoint inhibitor induced pneumonitis), fibrosis, and type 2 inflammatory disorders comprising administering anti-alarmin binding molecules to a subject in need thereof. In son embodiments treatment comprises administering one or more checkpoint inhibitors conjugated to a therapeutic moiety comprising a cytotoxic agent, a therapeutic agent, a radioisotope, an ultrasound sensitizer, or an exosome secretion inhibitor.

Abstract: A lawn mower includes a frame, an operator support, a blade assembly, a motor assembly, a steering assembly, one or more sensors and one or more processors. The frame is supported on rotatable wheels for movement over a ground surface. The operator support is configured to support the entire weight of an operator of the lawn mower during use thereof. The blade assembly comprises one or more blades. The motor assembly is configured to: drive the wheels so as to move the frame along the ground surface; and drive the one or more blades relative to the ground surface to cut grass. The steering assembly is configured to manipulate the steering direction of the wheels. The one or more processors are configured to control one or more components of the lawn mower based on input received from the one or more sensors.

Abstract: A system for treating food, the system including: a direct barrier discharge system including a pair of electrodes separated by a gap of at least 0.5 cm, wherein the direct barrier discharge system is configured to provide a feed gas between the electrodes, wherein the feed gas includes nitrogen and water, wherein a content of nitrogen in the feed gas is at least 75 vol % based on a total volume of the feed gas, and a relative humidity of the feed gas is at least 50% RH, wherein a content of oxygen in the feed gas is less than 1.5 vol % based on a total volume of the feed gas, and wherein the direct barrier discharge system is configured to provide an electric potential between the electrodes to generate a working gas having an ozone content of less than 20 ppm, based on a total volume of the working gas.

Abstract: A lawn mower includes a frame, an operator support, a blade assembly, a steering system, a motor assembly, a sensor and one or more processors. The operator support is coupled to the frame and is configured to support the entire weight of an operator of the lawn mower during use thereof. The motor assembly is configured to drive rotatable wheels so as to move the frame along the ground surface and drive at least one blade relative to the ground surface to cut grass. Sensor and processor to detect the an edge between an unmowed area of grass and a mowed area of grass and control the motor assembly stop driving the at least one blade, the wheels, or both based on the input from the sensor.

Abstract: Disclosed are compositions and methods related to anti-IL-17A antibodies and antigen binding fragments thereof. Additionally provided are bi-specific binding proteins comprising the anti-IL-17A binding domains. Additionally provided are methods of use for the compounds and compositions described herein in the treatment of inflammatory diseases and ocular disorders.

Abstract: An impact tool includes a controller configured to control power being delivered to the and operable in one of: (a) a normal mode where the controller allows power to be delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a normal transition torque; and (b) a control mode where the controller controls power being delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a control transition torque that is greater than the normal transition torque.

Abstract: An impact tool includes a controller configured to control power being delivered to the and operable in one of: (a) a normal mode where the controller allows power to be delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a normal transition torque; and (b) a control mode where the controller controls power being delivered to the motor so that the impact mechanism transitions from operation in the rotary mode to operation in the impacting mode when an output torque exceeds a control transition torque that is greater than the normal transition torque.

Abstract: A plasma treatment device includes dielectric plates arranged in parallel, sets of active electrodes disposed on outwardly facing sides of the dielectric plates, respectively, and ground electrodes interposed between inwardly facing sides of the dielectric plates. The sets of active electrodes and the ground electrodes are arranged to define a plasma treatment zone, which exhibits multi-axis symmetry and which is receptive of particles, and are operable to generate plasma for plasma treating the particles therein.

Abstract: A tape rule comprises a blade, a reel, a spring, a lock, and a housing. The blade comprises a substrate and a coating. The coating is configured to provide color, environmental protection, and/or abrasion resistance. In some embodiments, (1) the coating is formed from non-polymer materials; (2) the blade comprises reinforcements metallurgically bonded to the blade at or near a free end; (3) measurement indicia comprise laser marked portions of the substrate that create color contrasts with other portions of the substrate; (4) the measurement indicia comprise portions of the substrate visible through gaps in the coating; (5) the measurement indicia comprise voids in the substrate filled with a coating material having a contrasting color; and/or (6) the substrate has a surface texture configured to change an appearance of the coating relative to an appearance of the coating on an as-rolled surface finish of the metal substrate.