Abstract: The present disclosure encompasses systems, methods, and compositions for diagnosing a subject for a high-grade advanced pre-malignant lesions or colorectal cancer (CRC) disease state by ascertaining the presence of certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from the subject. Specific embodiments encompass methods of measuring certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from subjects known to have or suspected of having a high-grade advanced pre-malignant lesions or CRC disease state or subjects undergoing routine health care maintenance for possible presence of a high-grade advanced pre-malignant lesions or CRC disease state. The disclosure provides systems, methods, and compositions to identify subjects at-risk for CRC or high-grade advanced pre-malignant lesions and increases subject colonoscopy compliance, in specific embodiments.

Abstract: The present disclosure encompasses systems, methods, and compositions for diagnosing a subject for an AA or colorectal cancer (CRC) disease state by ascertaining the presence of certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from the subject. Specific embodiments encompass methods of measuring certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from subjects known to have or suspected of having an AA or CRC disease state or subjects undergoing routine health care maintenance for possible presence of an AA or CRC disease state. The disclosure provides systems, methods, and compositions to identify subjects at-risk for CRC or AA and increases subject colonoscopy compliance, in specific embodiments.

Abstract: The present disclosure encompasses systems, methods, and compositions for diagnosing a subject for an AA or colorectal cancer (CRC) disease state by ascertaining the presence of certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from the subject. Specific embodiments encompass methods of measuring certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from subjects known to have or suspected of having an AA or CRC disease state or subjects undergoing routine health care maintenance for possible presence of an AA or CRC disease state. The disclosure provides systems, methods, and compositions to identify subjects at-risk for CRC or AA and increases subject colonoscopy compliance, in specific embodiments.

Abstract: A mobile phone cover is provided comprising: a holder 120, 1120, 2120, 3120 for receiving and retaining a mobile phone 108, the mobile phone comprising an energy supply; a portable charging device 106, 1106, 2106, 3106 having two or more charging stations 110, 1110, 2110, 3110, each charging station 110, 1110, 2110, 3110 being configured and arranged for receiving and retaining a rechargeable instrument 104, the rechargeable instrument 104 comprising an energy storage; the portable charging device 106, 1106, 2106, 3106 being further configured and arranged: to transfer energy, in use, from the energy supply of the mobile phone 108, placed in the holder, to the two or more charging stations 110, 1110, 2110, 3110; and to transfer energy, in use, from the charging stations 110, 1110, 2110, 3110 to the energy storage of the rechargeable instrument 104 placed in the respective charging station 110, 1110, 2110, 3110.

Abstract: An apparatus including a display surface for presenting an image of a user; a light emitting portion for using light to convey semantic information to the user; a sensor for measuring the position of the user relative to the light emitting portion; and a control unit to control the light emitting portion based on the measured position of the user relative to the light emitting portion so as to minimize an effect of the light conveying the semantic information provided by the light emitting portion on the presented image of the user.

Abstract: An apparatus including a display surface for presenting an image of a user; a light emitting portion for using light to convey semantic information to the user; a sensor for measuring the position of the user relative to the light emitting portion; and a control unit to control the light emitting portion based on the measured position of the user relative to the light emitting portion so as to minimize an effect of the light conveying the semantic information provided by the light emitting portion on the presented image of the user.

Abstract: An apparatus including a display surface for presenting an image of a user; a light emitting portion for using light to convey semantic information to the user; a sensor for measuring the position of the user relative to the light emitting portion; and a control unit to control the light emitting portion based on the measured position of the user relative to the light emitting portion so as to minimize an effect of the light conveying the semantic information provided by the light emitting portion on the presented image of the user.

Abstract: An implantable stimulator is provided having a conformable foil-like substrate, having a longitudinal axis extending from a pulse generator to a distal end of the substrate. The substrate comprising one or more adjacent polymeric substrate layers and an electrode array. The electrode array having a first and second electrode where one or more electrical interconnections are comprised in the substrate. The conformable foil-like substrate has a maximum thickness of 0.5 millimeter or less, proximate the electrodes. By providing a more easily patternable multilayer substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array user comfort may be increased through application of energy to tissue by the implantable stimulator.

Abstract: A system to illuminate fruit and/or vegetables in the food storage facility, comprising a lamp (8) and a controller (12). The lamp is operable to provide the illumination with a first light output and a second light output, the first light output having a higher intensity and at least a red-bias spectrum relative to the second light output. Further, the system comprises a controller for controlling the illumination of the fruit and/or vegetables in the food storage facility by controlling the lamp. The controller is configured to apply the illumination in a sequence comprising a period of darkness, followed by the first light output for a first period, then followed by the second light output for a second period.

Abstract: An implantable stimulator is provided having a substrate comprising a conformable portion with an electrode array, and a pulse generator. A plurality of electrical interconnections are positioned between the surfaces of the substrate. The conformable portion has a thickness equal to or less than 0.5 millimeters. Optionally, one or more encapsulation layers may be provided. Optionally, one or adhesion layers may also be provided comprising a ceramic material. By providing a more easily patternable substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array, user comfort may be increased. The one or more adhesion layers improve the performance of the encapsulation.

Abstract: A system to illuminate fruit and/or vegetables in the food storage facility, comprising a lamp (8) and a controller (12). The lamp is operable to provide the illumination with a first light output and a second light output, the first light output having a higher intensity and at least a red-bias spectrum relative to the second light output. Further, the system comprises a controller for controlling the illumination of the fruit and/or vegetables in the food storage facility by controlling the lamp. The controller is configured to apply the illumination in a sequence comprising a period of darkness, followed by the first light output for a first period, then followed by the second light output for a second period.

Abstract: An implantable stimulator is provided having a conformable foil-like substrate, having a longitudinal axis extending from a pulse generator to a distal end of the substrate. The substrate comprising one or more adjacent polymeric substrate layers and an electrode array. The electrode array having a first and second electrode where one or more electrical interconnections are comprised in the substrate. The conformable foil-like substrate has a maximum thickness of 0.5 millimeter or less, proximate the electrodes. By providing a more easily patternable multilayer substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array user comfort may be increased through application of energy to tissue by the implantable stimulator.

Abstract: A main body of doctor blade chambers including a first portion configured to hold a first doctor blade, a second portion configured to hold a second doctor blade, a third portion connecting the first portion and the second portion, a cavity intended to receive ink and defined at least by the first portion, the second portion and the third portion, characterized in that the main body is a single closed hollow profile extending along a longitudinal main axis X-X, the main body being made of pultruded composite material.

Abstract: A mobile phone cover is provided comprising: a holder 120, 1120, 2120, 3120 for receiving and retaining a mobile phone 108, the mobile phone comprising an energy supply; a portable charging device 106, 1106, 2106, 3106 having two or more charging stations 110, 1110, 2110, 3110, each charging station 110, 1110, 2110, 3110 being configured and arranged for receiving and retaining a rechargeable instrument 104, the rechargeable instrument 104 comprising an energy storage; the portable charging device 106, 1106, 2106, 3106 being further configured and arranged: to transfer energy, in use, from the energy supply of the mobile phone 108, placed in the holder, to the two or more charging stations 110, 1110, 2110, 3110; and to transfer energy, in use, from the charging stations 110, 1110, 2110, 3110 to the energy storage of the rechargeable instrument 104 placed in the respective charging station 110, 1110, 2110, 3110.

Abstract: An implantable stimulator is provided having a conformable foil-like substrate, having a longitudinal axis extending from a pulse generator to a distal end of the substrate. The substrate comprising one or more adjacent polymeric substrate layers and an electrode array. The electrode array having a first and second electrode where one or more electrical interconnections are comprised in the substrate. The conformable foil-like substrate has a maximum thickness of 0.5 millimeter or less, proximate the electrodes. By providing a more easily pattemable multilayer substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array user comfort may be increased through application of energy to tissue by the implantable stimulator.

Abstract: An implantable stimulator is provided having a conformable foil-like substrate, having a longitudinal axis extending from a pulse generator to a distal end of the substrate. The substrate comprising one or more adjacent polymeric substrate layers and an electrode array. The electrode array having a first and second electrode where one or more electrical interconnections are comprised in the substrate. The conformable foil-like substrate has a maximum thickness of 0.5 millimeter or less, proximate the electrodes. By providing a more easily patternable multilayer substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array user comfort may be increased through application of energy to tissue by the implantable stimulator.

Abstract: The use of neurostimulation leads in the craniofacial region is associated with skin erosion and lead migration. The cylindrical shape and associated thickness of state-of-the-art leads results in the lead eroding through the skin or results in the lead being displaced so that the electrodes no longer cover the targeted nerves. An implantable stimulator 100,1110 is provided having a substrate 300, 1400 comprising a conformable portion with an electrode array, and a pulse generator 500. A plurality of electrical interconnections 250, 1210 are positioned between the surfaces of the substrate The conformable portion has a thickness equal to or less than 0.5 millimeters. Optionally, one or more encapsulation layers 1300 may be provided. Optionally, one or adhesion layers 1500 may also be provided comprising a ceramic material.

Abstract: A mobile phone cover is provided comprising: a holder 120, 1120, 2120, 3120 for receiving and retaining a mobile phone 108, the mobile phone comprising an energy supply; a portable charging device 106, 1106, 2106, 3106 having two or more charging stations 110, 1110, 2110, 3110, each charging station 110, 1110, 2110, 3110 being configured and arranged for receiving and retaining a rechargeable instrument 104, the rechargeable instrument 104 comprising an energy storage; the portable charging device 106, 1106, 2106, 3106 being further configured and arranged: to transfer energy, in use, from the energy supply of the mobile phone 108, placed in the holder, to the two or more charging stations 110, 1110, 2110, 3110; and to transfer energy, in use, from the charging stations 110, 1110, 2110, 3110 to the energy storage of the rechargeable instrument 104 placed in the respective charging station 110, 1110, 2110, 3110.

Abstract: An adaptive lighting system (100), a (virtual) mirror arrangement, a method of controlling light sources of an adaptive light sources, a method of controlling a virtual mirror and a computer program product are provided. The adaptive lighting system is for a mirror component that is configured to show a mirror image of the user at the mirror surface of the mirror component. The adaptive lighting system comprises a plurality of individually controllable light sources (111 . . . 119), a sensor (102), and a controller (104). The sensor detects a relative orientation of the head of the user with respect to the mirror surface. The controller generates control signals (121 . . . 129) for the individually controllable light sources on the basis of the sensor signal. The controller generates the control signals to obtain a lower emission of light towards eyes of the user if the sensor signal indicates that the head is turned left sidewards, upwards, right sidewards and/or downwards.

Abstract: According to an aspect, there is provided an apparatus (100) comprising a display surface (102) for presenting an image of a user; a light emitting portion (104) for using light to convey semantic information to the user; a sensor (108) for measuring the position of the user relative to the light emitting portion (104); and a control unit (106) configured to control the light emitting portion (104) based on the measured position of the user relative to the light emitting portion (104) so as to minimise the effect of the light conveying the semantic information provided by the light emitting portion (104) on the presented image of the user.