Patents by Inventor Daniel Y. Chu
Daniel Y. Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11828084Abstract: A door-unlatching device including a lower actuator including a foot-pad, an upper actuator including a lever-arm and a handle-mount attachable to a handle of door-latch, and a link coupled to the foot-pad and the lever-arm, wherein the lever-arm is movable between a first position and a second position relative to the handle-mount. It can be set to either engaged mode which allows either hand or foot to operate; or disengaged mode to allow only hand to operate which the door can also be locked from entry as by a normal door latch.Type: GrantFiled: February 1, 2021Date of Patent: November 28, 2023Inventor: Daniel Y. Chu
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Publication number: 20200384461Abstract: Lateral flow device pump housings and methods of making such housings are provided.Type: ApplicationFiled: August 22, 2018Publication date: December 10, 2020Applicant: Bio-Rad Laboratories, Inc.Inventors: William STRONG, DANIEL Y. CHU
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Patent number: 10802264Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.Type: GrantFiled: October 10, 2017Date of Patent: October 13, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Zuo Cheng Shen, Daniel Y. Chu, Nicholas Doe, Emmanuel Quiroz, Amber Iraeta
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Patent number: 10466156Abstract: A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.Type: GrantFiled: August 19, 2015Date of Patent: November 5, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Daniel Y. Chu, Paul J. Patt, Roger Tong
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Patent number: 10343165Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.Type: GrantFiled: December 30, 2016Date of Patent: July 9, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Amir Sadri, Kun Guo, Daniel Y. Chu, Nenad Kircanski, Paul J. Patt, Tal Rosenzweig
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Publication number: 20180031819Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.Type: ApplicationFiled: October 10, 2017Publication date: February 1, 2018Inventors: Zuo Cheng SHEN, Daniel Y. CHU, Nicholas DOE, Emmanuel QUIROZ
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Patent number: 9850517Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 ?m or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.Type: GrantFiled: September 27, 2013Date of Patent: December 26, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Tom McCollum, Paul Patt, Frank Shen, Daniel Y. Chu, Don Flory, Mike Griffin, Xin Heng, Eli Hefner
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Patent number: 9829696Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.Type: GrantFiled: May 1, 2014Date of Patent: November 28, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Zuo Cheng Shen, Daniel Y. Chu, Nicholas Doe, Emmanuel Quiroz
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Publication number: 20170241888Abstract: A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.Type: ApplicationFiled: August 19, 2015Publication date: August 24, 2017Applicant: BIO-RAD LABORATORIES, INC.Inventors: Daniel Y. Chu, Paul J. Patt, Roger Tong
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Publication number: 20170239663Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.Type: ApplicationFiled: March 9, 2017Publication date: August 24, 2017Inventors: Jeff CEREMONY, Daniel Y. CHU
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Publication number: 20170128941Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.Type: ApplicationFiled: December 30, 2016Publication date: May 11, 2017Inventors: Amir Sadri, Kun Guo, Daniel Y. Chu, Nenad Kircanski, Paul J. Patt, Tal Rosenzweig
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Patent number: 9623414Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.Type: GrantFiled: December 11, 2014Date of Patent: April 18, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Jeff Ceremony, Daniel Y. Chu
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Patent number: 9535000Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.Type: GrantFiled: September 5, 2014Date of Patent: January 3, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Kun Guo, Amir M. Sadri, Daniel Y. Chu, Nenad Kircanski, Paul J. Patt, Tal Rosenzweig
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Patent number: 9149809Abstract: Rapid and uniform temperature changes in the wells of a microplate or any thin-walled plate that contains an array of reaction wells or sample receptacles are achieved by the use of heating and cooling elements with a vapor chamber interposed between such elements and the microplate. The upper surface of the vapor chamber and the underside of the sample plate in certain embodiments are complementary in shape, i.e., they have identical but oppositely directed contours in the areas around each of the sample receptacles, to provide continuous surface contact along the surface of each receptacle. In other embodiments, an intermediary plate is placed between the vapor chamber and the well plate, with the top surface of the intermediary plate being complementary in shape to the underside of the well plate.Type: GrantFiled: May 1, 2012Date of Patent: October 6, 2015Assignee: BIO-RAD LABORATORIES, INC.Inventors: Kun Guo, Daniel Y. Chu, Paul Patt, Amir Sadri, Roger Tong
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Publication number: 20150258547Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.Type: ApplicationFiled: December 11, 2014Publication date: September 17, 2015Inventors: German Arciniegas, Jeff Ceremony, Daniel Y. Chu, Charles W. Ragsdale
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Publication number: 20150093743Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.Type: ApplicationFiled: September 5, 2014Publication date: April 2, 2015Inventors: Amir M. SADRI, Kun GUO, Daniel Y. CHU, Nenad KIRCANSKI, Paul J. PATT, Tal ROSENZWEIG
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Patent number: 8945881Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.Type: GrantFiled: January 5, 2010Date of Patent: February 3, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: German Arciniegas, Jeff Ceremony, Daniel Y. Chu, Charles W. Ragsdale
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Publication number: 20140327757Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.Type: ApplicationFiled: May 1, 2014Publication date: November 6, 2014Applicant: Bio-Rad Laboratories, Inc.Inventors: Zuo Cheng SHEN, Daniel Y. CHU, Nicholas DOE, Emmanuel QUIROZ
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Patent number: 8802000Abstract: A multi-well plate with wells having ultra-thin walls and yet with sufficient structural rigidity to allow reliable use of the plate in automated instrumentation is formed by first forming a plate blank by injection molding, the blank being of a thickness that provides the desired rigidity, and then subjecting the blank to vacuum forming to stretch designated areas in the blank to form wells or to extend wells already formed, the stretching resulting in a reduction in thickness of the molded resin at the walls of the wells only.Type: GrantFiled: July 29, 2009Date of Patent: August 12, 2014Assignee: Bio-Rad Laboratories, Inc.Inventors: Daniel Y. Chu, Hui Du
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Patent number: 8784753Abstract: A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.Type: GrantFiled: July 17, 2012Date of Patent: July 22, 2014Assignee: Bio-Rad Laboratories, Inc.Inventors: Jeffry M. Ceremony, Daniel Y. Chu, Deepak K. Doshi, Rhoel Rumbaoa, Dennis W. Loring, Paul J. Patt, Cliff Baldwin