Patents by Inventor Daniel Yansura

Daniel Yansura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20090087429
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: October 17, 2007
    Publication date: April 2, 2009
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Sarah G. Hymowitz, Daniel Tumas, Melissa A. Starovasnik, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Mickey Williams, William I. Wood, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20090035261
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hosT-cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: June 19, 2008
    Publication date: February 5, 2009
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gumey, Hanzhong Li, Kenneth Hillan, Sarah G. Hymowitz, Daniel Tumas, Melissa A. Starovasnik, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Mickey Williams, William I. Wood, Daniel Yansura
  • MONOVALENT ANTIBODY FRAGMENTS USEFUL AS THERAPEUTICS
    Publication number: 20080063641
    Abstract: The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.
    Type: Application
    Filed: October 3, 2006
    Publication date: March 13, 2008
    Inventors: Arthur Huang, Ralph Schwall, Daniel Yansura
  • Methods and compositions for increasing antibody production
    Publication number: 20070128111
    Abstract: The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
    Type: Application
    Filed: May 22, 2006
    Publication date: June 7, 2007
    Applicant: GENENTECH, INC.
    Inventors: Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070065909
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: February 9, 2006
    Publication date: March 22, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070020725
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: May 22, 2006
    Publication date: January 25, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20070020735
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: September 29, 2006
    Publication date: January 25, 2007
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gumey, Kenneth Hillan, Sarah Hymowitz, Hanzhong Li, James Pan, Melissa Starovasnik, Daniel Tumas, Menno Lookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • Process for production of polypeptides
    Publication number: 20060286640
    Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 21, 2006
    Inventors: Eriks Paegle, Dorothea Reilly, Daniel Yansura
  • Process for production of polypeptides
    Publication number: 20060216784
    Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
    Type: Application
    Filed: January 26, 2006
    Publication date: September 28, 2006
    Inventors: Eriks Paegle, Dorothea Reilly, Daniel Yansura
  • Heteromultimeric molecules
    Publication number: 20060204493
    Abstract: The invention provides heteromultimeric antibodies, and methods of making these antibodies at high yields and purity. The invention also provides methods and compositions for using these antibodies.
    Type: Application
    Filed: September 1, 2005
    Publication date: September 14, 2006
    Inventors: Arthur Huang, Barbara Moffat, Daniel Yansura
  • Methods for producing soluble membrane-spanning proteins
    Publication number: 20060172385
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 3, 2006
    Applicant: GENENTECH, INC.
    Inventors: James Ernst, Daniel Yansura, Hok Seon Kim
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060134755
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 22, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060088916
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: April 27, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060088917
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: April 27, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • Monovalent antibody fragments useful as therapeutics
    Publication number: 20050227324
    Abstract: The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: Arthur Huang, Ralph Schwall, Daniel Yansura
  • Prokaryotically produced antibodies and use thereof
    Publication number: 20050170464
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Methods and compositions for increasing antibody production
    Publication number: 20050048572
    Abstract: The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
    Type: Application
    Filed: October 30, 2003
    Publication date: March 3, 2005
    Inventors: Dorothea Reilly, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20040043397
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: April 7, 2003
    Publication date: March 4, 2004
    Applicant: Genentech, Inc.
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel Yansura
  • PUMPCn compositions and uses thereof
    Publication number: 20040005598
    Abstract: The present invention is directed to novel polypeptides Protein Upregulated in Metastatic Prostate Cancer (PUMPCn) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 19, 2003
    Publication date: January 8, 2004
    Applicant: Genentech, Inc.
    Inventors: Brigitte DeVaux, David Eberhard, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Kenneth J. Hillan, Colin K. Watanabe, William I. Wood, Daniel Yansura, Zemin Zhang
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20030203451
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: June 10, 2003
    Publication date: October 30, 2003
    Applicant: Genentech, Inc.
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Sarah G. Hymowitz, Daniel Tumas, Melissa A. Starovasnik, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Mickey Williams, William I. Wood, Daniel Yansura