Abstract: Provided herein are, inter alia, novel antibodies that bind to fms-like tyrosine kinase 3 (FLT3) thereby effectively targeting cells expressing FLT3. The antibodies provided herein may be used, inter alia, for therapeutic cancer applications, including, in some embodiments, treatment of multiple cancer types, which may include acute myeloid leukemia (AML), lymphoblastic leukemia (ALL), lung cancer, breast cancer, pancreatic cancer, ovarian cancer, colorectal cancer, renal cancer, or glioblastoma.

Abstract: Provided herein are, inter alia, novel antibodies that bind to cadherin-17 (CDH17) thereby effectively targeting cells expressing CHD17. The antibodies provided herein may be used, inter alia, for therapeutic cancer applications, including, in some embodiments, treatment of multiple cancer types, which may include gastrointestinal cancer, colorectal cancer, stomach cancer, pancreas cancer, neuroendocrine cancer, or ovarian cancer.

Abstract: A portable device, and more particularly a portable device for vaporizing materials such as oils for inhalation. Also, methods for vaporizing materials and methods of operating portable vaporizing devices. In addition, networks for providing operational features and/or instructions for operation of vaporizing devices and for monitoring and collecting operational data. In preferred embodiments, a vaporizing device and/or methods for operating a vaporizing device wherein the vaporizing device includes one or more of the following features: security features to regulate operation of the device; automatic detection of vaporizing material identity; user experience monitoring and data collection; and/or temperature adjustment of vaporizing material based on detected material for vaporization.

Abstract: A filter device of the present disclosure includes at least a sheet-shaped fiber structure having a plurality of fibers made of amorphous silicon dioxide, wherein the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure. A filter device of the present disclosure corresponds to an analysis device including: a substrate; a flow path formed on the substrate; and a sheet-shaped fiber structure provided on the inner wall of the flow path, wherein the sheet-shaped fiber structure includes a plurality of fibers made of amorphous silicon dioxide, and the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A filter device of the present disclosure includes at least a sheet-shaped fiber structure having a plurality of fibers made of amorphous silicon dioxide, wherein the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure. A filter device of the present disclosure corresponds to an analysis device including: a substrate; a flow path formed on the substrate; and a sheet-shaped fiber structure provided on the inner wall of the flow path, wherein the sheet-shaped fiber structure includes a plurality of fibers made of amorphous silicon dioxide, and the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon; and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

Abstract: The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CR7R8)t(C6-C14 aryl), and —(CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, —OR7, and —N(R7R8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.

Abstract: The present invention provides a method for producing metabolites of capravirine (2-carbamoyloxymethyl-5-(3,5-dichlorophenyl)thio-4-isopropyl-1-(4-pyridyl)methyl-1H-imidazole) via whole cell biotransformation using fungi and bacterial cells as oxygenation catalysts.