Abstract: An orthopedic instrument, comprising a pair of pivotally-connected arms, extending beyond a pivot axis of a first pivot; a pair of feet mounted to ends of the pair of pivotally-connected arms; and a quadrilateral linkage configured to maintain parallelism between the pair of feet over a range of angles and to selectively alter a distance between the pair of feet.

Abstract: This invention relates to macrostructures (and pharmaceutical formulations containing them) that include an antiparallel coiled-coil. wherein the antiparallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-f3-T2 (I) T3-f0-g?0-a?1-b?1-c?1-d?1-e?1-f?1-g?1-a?2-b?2-c?2-d?2-e?2-f?2-g?2-a?3-b?3-c?3-d?3-e?3-T4 (II), as described in the present application. Methods of using these macrostructures are also disclosed.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: A method includes determining a preprocessed audio signal by removing some noise from an input audio signal. Here, portions of the preprocessed audio signal that include speech are separated by portions of the preprocessed audio signal that include residual noise. Additionally, the method includes determining an amplified signal by suppressing the preprocessed audio signal over the portions that include residual noise, and maintaining the preprocessed audio signal over the portions that include speech.

Abstract: A method includes determining a first filtered signal based on an audio signal; determining a second filtered signal based on the audio signal; determining, based on the first filtered signal and the second filtered signal, a portion of the audio signal corresponding to a sharp noise; determining, based on the first filtered signal and the second filtered signal, a gain signal that, for the portion of the audio signal corresponding to the sharp noise, has a value that is smaller than a value of the gain signal for the remaining portion of the audio signal; and suppressing, based on the gain signal, the sharp noise from an amplifier input signal determined based on the audio signal.

Abstract: A method includes determining a first filtered signal based on an audio signal; determining a second filtered signal based on the audio signal; determining, based on the first filtered signal and the second filtered signal, a portion of the audio signal corresponding to a sharp noise; determining, based on the first filtered signal and the second filtered signal, a gain signal that, for the portion of the audio signal corresponding to the sharp noise, has a value that is smaller than a value of the gain signal for the remaining portion of the audio signal; and suppressing, based on the gain signal, the sharp noise from an amplifier input signal determined based on the audio signal.

Abstract: A method includes determining a preprocessed audio signal by removing some noise from an input audio signal. Here, portions of the preprocessed audio signal that include speech are separated by portions of the preprocessed audio signal that include residual noise. Additionally, the method includes determining an amplified signal by suppressing the preprocessed audio signal over the portions that include residual noise, and maintaining the preprocessed audio signal over the portions that include speech.

Abstract: A method of removing a noise signal from an input signal, the method including receiving a pure noise signal and an input signal including the noise signal; determining whether the pure noise signal is a static noise signal or a non-static noise signal; and removing the noise signal from the input signal according to whether the noise signal is determined to be the static noise signal or the non-static noise signal.

Abstract: A method of removing a noise signal from an input signal, the method including receiving a pure noise signal and an input signal including the noise signal; determining whether the pure noise signal is a static noise signal or a non-static noise signal; and removing the noise signal from the input signal according to whether the noise signal is determined to be the static noise signal or the non-static noise signal.

Abstract: There are computerized processes for financial planning for individuals and groups whose financial portfolio would be subject to tax on certain events. But these processes do not take into account these taxes when optimizing investment decisions, since taxes levied on investment outcomes, typically on income and realized capital gains, may have an important impact on net portfolio results. This invention is a method for transforming the usual pretax information for calculation of an efficient frontier, unique to an investor's portfolio, in such a manner that any portfolio on the calculated frontier is efficient after incorporating the effect of taxes on the risk and expected return of each asset class permitted in the investor's portfolio. This invention addresses how this may be done and how certain facets of the process may be incorporated into a computer program or system so as to provide convenience to the potential user.

Abstract: There are computerized processes for financial planning for individuals and groups whose financial portfolio would be subject to tax on certain events. But these processes do not take into account these taxes when optimizing investment decisions, since taxes levied on investment outcomes, typically on income and realized capital gains, may have an important impact on net portfolio results. This invention is a method for transforming the usual pretax information for calculation of an efficient frontier, unique to an investor's portfolio, in such a manner that any portfolio on the calculated frontier is efficient after incorporating the effect of taxes on the risk and expected return of each asset class permitted in the investor's portfolio. This invention addresses how this may be done and how certain facets of the process may be incorporated into a computer program or system so as to provide convenience to the potential user.