Abstract: Provided herein are dendrimer-targeting agent conjugates comprising a dendrimer, the dendrimer comprising a core unit and lysine or lysine analogue building units, a HER2 targeting agent which is a peptidic moiety having a molecular weight of up to about 80 kDa and comprising an antigen-binding site, which is covalently linked by a spacer group, and a therapeutic agent which is covalently linked to a surface building unit of the dendrimer. Also provided herein are compositions comprising the conjugates, and therapeutic methods using the conjugates, particularly for treating cancer.

Abstract: A method of forming an Al—Zn—Si—Mg alloy coating on a strip that includes dipping strip into a bath of molten Al—Zn—Si—Mg alloy and forming a coating of the alloy on the strip, with the Al—Zn—Si—Mg alloy containing in % by weight: Al: 2 to 19%, Si: 0.1 to 2%, Mg: 1 to 10%, and Zn: 80 to 97%, and with the bath having a molten metal layer and a top dross layer on the metal layer, and the method including providing Ca in the composition of the bath to minimise the top dross layer in the molten bath.

Abstract: A method and apparatus for casting thin strip including assembling a pair of counter-rotating casting rolls forming a gap between the casting surfaces of the rolls at a nip between the rolls through which metal strip can be cast; assembling side dams adjacent end portions of the rolls to permit a casting pool of molten metal to be formed on the casting surfaces; counter-rotating the rolls such that the casting surfaces each travel inwardly toward the nip to form metal shells on the surfaces of the rolls and deliver a cast strip downwardly from the gap between the rolls with a mushy internal portion; and providing a drive mechanism to oscillate the gap amplitude between the casting rolls between ±5 and ±50 microns at a frequency between 1 and 7 hertz to vary thickness of the mushy internal portion in the cast strip and reduce chatter during casting.

Abstract: A method and apparatus for casting thin strip including assembling a pair of counter-rotating casting rolls forming a gap between the casting surfaces of the rolls at a nip between the rolls through which metal strip can be casted; assembling side dams adjacent end portions of the rolls to permit a casting pool of molten metal to be formed on the casting surfaces; counter-rotating the rolls such that the casting surfaces each travel inwardly toward the nip to form metal shells on the surfaces of the rolls and deliver a cast strip downwardly from the gap between the rolls with a mushy internal portion; and providing a drive mechanism to oscillate the gap amplitude between the casting rolls between ±5 and ±50 microns at a frequency between 1 and 7 hertz to vary thickness of the mushy in the cast strip and reduce chatter during casting.

Abstract: A developer is enabled to select a website for editing. The website is defined by a plurality of files stored at a server. The website files stored at the server include files containing code and may optionally include one or more un-editable files. In response to the developer selecting the website for editing, a call is issued to download a copy of the files containing code from the server to store in a cache at the computing device. The developer is enabled to edit the files containing code to generate an edited version of the website, including being enabled to edit a downloaded copy of a file containing code in the cache when a copy of at least one other file containing code has not yet been downloaded to the cache in response to the call. The developer is enabled to display the edited version of the website.

Abstract: A method of forming an Al—Zn—Si—Mg alloy coating on a strip that includes dipping strip into a bath of molten Al—Zn—Si—Mg alloy and forming a coating of the alloy on the strip, with the Al—Zn—Si—Mg alloy containing in % by weight: Al: 2 to 19%, Si: 0.1 to 2%, Mg: 1 to 10%, and Zn: 80 to 97%, and with the bath having a molten metal layer and a top dross layer on the metal layer, and the method including providing Ca in the composition of the bath to minimise the top dross layer in the molten bath.