Abstract: The present disclosure relates to a method for setting a valve, wherein setting of a property of the valve and testing of a function of the valve takes place, wherein the setting and the testing take place in an automated manner. The property of the valve may be magnetization of one or more components, for example magnets, of the valve, and/or the function of the valve is a behavior of the valve according to a characteristic based on the magnetization.

Abstract: The disclosure relates to an assembly press for press-joining components, which comprises a linear unit that is configured for moving a component placed thereon back and forth along one direction, an optical measuring unit comprising a detection region directed onto a portion of the linear unit in order to measure a component placed on the linear unit, and a gripper stamp which is configured for lifting a first component, optionally an inner partner, from the linear unit and, after displacement of the linear unit, for joining it to a second component, optionally an outer partner, placed in the detection region.

Abstract: The disclosure relates to a soldering device for soldering components, and comprises a linear unit that is configured for moving a component placed thereon back and forth along one direction, an optical measuring unit comprising a detection region directed onto a portion of the linear unit in order to measure a component placed on the linear unit, and a soldering unit which is configured for soldering a first constituent of the component, preferably a sphere, to a second constituent of the component, preferably a wire.

Abstract: The disclosure relates to a welding device for welding components which comprises a linear unit that is configured for moving a component placed thereon back and forth along one direction, an optical measuring unit comprising a detection region directed onto a portion of the linear unit in order to measure a component placed on the linear unit, and a welding unit which is configured for lifting a first component, optionally a sphere, from the linear unit and, after displacement of the linear unit, for welding it to a second component, optionally a wire, placed in the detection region.

Abstract: The disclosure relates to a method for preselecting at least one step part of an assembly module, comprising the steps of: measuring individual components which, in the mounted state together with at least one step part, create the assembly module, calculating a model of the assembly module using the dimensions obtained during the measurement of the individual components, and determining the dimensioning of the at least one step part on the basis of the calculated model and the allowable tolerances of the assembly module.

Abstract: Provided herein are new crystalline form(s) of succinate salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (also known as ribociclib), pharmaceutical compositions comprising the same, methods of treatment using the same and methods of making the same.

Abstract: Provided herein are new crystalline form(s) of succinate salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (also known as ribociclib), pharmaceutical compositions comprising the same, methods of treatment using the same and methods of making the same.

Abstract: The present invention relates to a method for adjusting a valve, in particular a servo valve comprising a first stage and a second stage, comprising the steps of: only partially limiting a range of movement of a valve spool which is configured to open and/or close at least one port of the valve so that the spool is movable; applying the valve with a fluid, and changing a position of a nozzle of the valve relative to a jet divider until the at least one port is completely closed by the movable spool. A method according to the invention is preferably used in the manufacture of an aircraft, preferably airplanes.

Abstract: Provided herein are new crystalline form(s) of succinate salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (also known as ribociclib), pharmaceutical compositions comprising the same, methods of treatment using the same and methods of making the same.

Abstract: Technologies are described for performing automated data integration, reconciliation, and/or self-healing using machine learning. For example, data integration can be checked using a reconciliation procedure. The number of times that the reconciliation is performed can be determined dynamically by a machine learning model. For each iteration, reconciliation can be performed to check integrated data against source data. If any reconciliation errors are found, then self-healing operations can be performed. Results of the reconciliation can be output. The reconciliation results can be used to update the machine learning model so that the machine learning model can dynamically adjust the number of iterations to perform based at least in part on reconciliation results.

Abstract: Technologies are described for performing automated data integration, reconciliation, and/or self-healing using machine learning. For example, data integration can be checked using a reconciliation procedure. The number of times that the reconciliation is performed can be determined dynamically by a machine learning model. For each iteration, reconciliation can be performed to check integrated data against source data. If any reconciliation errors are found, then self-healing operations can be performed. Results of the reconciliation can be output. The reconciliation results can be used to update the machine learning model so that the machine learning model can dynamically adjust the number of iterations to perform based at least in part on reconciliation results.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The invention provides a method and an apparatus for estimating an RMS current (Ic,rms) of an intermediate circuit capacitor (CZWK) for a complete system of a battery (1), an inverter (9) and an N-phase electrical machine (6), wherein, in the complete system, the inverter (9) converts a DC power received from the battery (1) for the purpose of energizing the electrical machine with N phase currents, and wherein the RMS current (Ic,rms) of the intermediate circuit capacitor to be estimated is calculated according to a calculation rule which is supplied with predefined switching times (tLow,off, tHigh,off) of the N phases of the electrical machine, measured phase currents (ISu, ISv, ISw) of N-1 phases or N phases of the electrical machine and a predefined battery direct current (IBatt) as input variables. This makes it possible to exactly estimate the RMS current (Ic,rms) of an intermediate circuit capacitor for any desired pulse patterns for controlling the inverter.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The invention provides a method and an apparatus for estimating an RMS current (Ic,rms) of an intermediate circuit capacitor (CZWK) for a complete system of a battery (1), an inverter (9) and an N-phase electrical machine (6), wherein, in the complete system, the inverter (9) converts a DC power received from the battery (1) for the purpose of energizing the electrical machine with N phase currents, and wherein the RMS current (Ic,rms) of the intermediate circuit capacitor to be estimated is calculated according to a calculation rule which is supplied with predefined switching times (tLow,off, tHigh,off) of the N phases of the electrical machine, measured phase currents (ISu, ISv, ISw) of N-1 phases or N phases of the electrical machine and a predefined battery direct current (IBatt) as input variables. This makes it possible to exactly estimate the RMS current (Ic,rms) of an intermediate circuit capacitor for any desired pulse patterns for controlling the inverter.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.