Patents by Inventor Daniel Zyla

Daniel Zyla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of [1-hydroxy-2-(1-imidazol-1-yl)- ethylidene]bisphosphonic acid
    Patent number: 8524912
    Abstract: A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
    Type: Grant
    Filed: October 17, 2009
    Date of Patent: September 3, 2013
    Assignee: Zaklady Farmaceutyczne Polpharma SA
    Inventors: Leszek Dembkowski, Mariusz Krzyzanowski, Robert Rynkiewicz, Roman Szramka, Zdzislaw Roznerski, Daniel Zyla, Janusz Rachon, Slawomir Makowiec
  • PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE] BISPHOSPHONIC ACID
    Publication number: 20120116092
    Abstract: A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
    Type: Application
    Filed: October 17, 2009
    Publication date: May 10, 2012
    Applicants: POLITECHNIKA GDANSKA, ZAKLADY FARMACEUTYCZNE POLPHARMA S.A
    Inventors: Leszek Dembkowski, Mariusz Krzyzanowski, Robert Rynkiewicz, Roman Szramka, Zdzislaw Roznerski, Daniel Zyla, Janusz Rachon, Slawomir Makowiec
  • PROCESS FOR THE PREPARATION OF SODIUM SALT OF 1-(((1(R)-(3-(2-(7-CHLORO-2-QUINOLINYL)-ETHENYL)PHENYL)-3-(2-(1-HYDROXY-1-METHYLETHYL)PHENYL)PROPYL)SULFANYL)METHYL)CYCLOPROPANEACETIC ACID
    Publication number: 20100069641
    Abstract: A novel process for the preparation of a sodium salt of 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methyl-ethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid, comprising: a) reacting a compound of Formula 1 with methanesulfonyl chloride in the presence of a tertiary amine to yield a crude solution of a compound of Formula 2; b) filtering the crude solution of compound of Formula 2 obtained in a) to remove solid amine hydrochloride, reacting the filtrate without isolation or further purification with a compound of Formula 3, and isolating 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid; c) reacting the 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid isolated in b) with tert-butylamine to yield a compound of formula 4; d) isolating and purifying the compound of formula 4; and e) converting th
    Type: Application
    Filed: April 30, 2008
    Publication date: March 18, 2010
    Applicant: ZAKLADY FARMACEUTYCZNE POLPHARMA S.A.
    Inventors: Daniel Zyla, Robert Rynkiewicz, Mariusz Krzyzanowski, Jan Ramza