Patents by Inventor Daniela Beccati

Daniela Beccati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160120896
    Abstract: The disclosure provides LMWH preparations and methods of analyzing LMWH preparations having at least one chain having a glycol split uronic acid residue (UG) in the preparation for structural signatures, and methods of producing such preparations based upon the analysis.
    Type: Application
    Filed: May 27, 2014
    Publication date: May 5, 2016
    Inventors: Jing Wang, Elaine Y. Sun, Kristaq Vezuli, Daniela Beccati, Birgit Schultes, Jennifer Ozug, Miroslaw Lech, Fei Yu
  • Patent number: 9182467
    Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: November 10, 2015
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
  • Patent number: 9068957
    Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature, wherein, e.g., the structural signature is indicative of the methods used to make the heparin preparation.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: June 30, 2015
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nur Sibel Gunay, Miroslaw Lech, Sucharita Roy, John Schaeck, Jennifer Ozug, Daniela Beccati, Ishan Capila
  • Publication number: 20140114056
    Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature, wherein, e.g., the structural signature is indicative of the methods used to make the heparin preparation.
    Type: Application
    Filed: February 21, 2012
    Publication date: April 24, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nur Sibel Gunay, Miroslaw Lech, Sucharita Roy, John Schaeck, Jennifer Ozug, Daniela Beccati, Ishan Capila
  • Patent number: 8617896
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: December 31, 2013
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Patent number: 8609632
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: December 17, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Sirajbhai Mamuwala, Ian David Fier, Yiwei Qi, Ishan Capila, Nur Sibel Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li
  • Patent number: 8435795
    Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin preparation.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: May 7, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Sucharita Roy
  • Patent number: 8252597
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: August 28, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Patent number: 8216851
    Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: July 10, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
  • Patent number: 8076149
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: December 13, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Publication number: 20110207919
    Abstract: Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin preparation.
    Type: Application
    Filed: January 18, 2011
    Publication date: August 25, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Sucharita Roy
  • Patent number: 7968082
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: June 28, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Jonathan Lansing
  • Publication number: 20100305022
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Sirajbhai Mamuwala, Ian David Fier, Yiwei Qi, Ishan Capila, Nur Sibel Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li
  • Publication number: 20100279269
    Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.
    Type: Application
    Filed: April 15, 2008
    Publication date: November 4, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
  • Patent number: 7816144
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: October 19, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Patent number: 7790466
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: September 7, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Publication number: 20100188084
    Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
    Type: Application
    Filed: April 15, 2008
    Publication date: July 29, 2010
    Applicant: Momenta Pharmaceuticals,Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
  • Publication number: 20070287683
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Application
    Filed: May 24, 2007
    Publication date: December 13, 2007
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Mamuwala, Ian Fier, Yiwei Qi, Ishan Capila, Nur Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li