Patents by Inventor Daniela BENADIKOVÁ

Daniela BENADIKOVÁ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
    Patent number: 11680052
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: June 20, 2023
    Assignee: MIKROCHEM SPOL. S R.O.
    Inventors: Daniela Benadiková, Juraj Cech, Erik Juhás, Vladimír Oremus, Vendel {hacek over (S)}mahovský
  • METHOD FOR PREPARATION OF 3,7-BIS-(DIMETHYLAMINO)-PHENOTHIAZIN-5-IUM CHLORIDE OR BROMIDE
    Publication number: 20210292288
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(dimethylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Applicant: MIKROCHEM spol. s r.o.
    Inventors: Daniela BENADIKOVÁ, Juraj CECH, Erik JUHÁS, Vladimír OREMUS, Vendel SMAHOVSKÝ
  • Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
    Patent number: 11059797
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(di-methylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 13, 2021
    Assignee: MIKROCHEM SPOL. S R.O.
    Inventors: Daniela Benadiková, Juraj Cech, Erik Juhás, Vladimír Oremus, Vendel {hacek over (S)}mahovský
  • METHOD FOR PREPARATION OF 3,7-BIS-(DIMETHYLAMINO)-PHENOTHIAZIN-5-IUM CHLORIDE OR BROMIDE
    Publication number: 20200010436
    Abstract: The present invention relates to: a process for preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide or chloride; a method of converting 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide to 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride; and the purification of 7-bis-(di-methylamino)-phenothiazin-5-ium chloride by crystallization from aqueous solution of hydrochloric acid, leading to a pharmaceutically acceptable 3,7-bis-(di-methylamino)-phenothiazin-5-ium chloride (methylthioninium chloride, methylene blue, MTC) of formula I below reported.
    Type: Application
    Filed: March 15, 2018
    Publication date: January 9, 2020
    Applicant: MIKROCHEM spol. s r.o.
    Inventors: Daniela BENADIKOVÁ, Juraj CECH, Erik JUHÁS, Vladimír OREMUS, Vendel SMAHOVSKÝ