Patents by Inventor Daniela Carmen Oniciu

Daniela Carmen Oniciu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALTS AND ESTERS OF APX3330 AND THERAPEUTIC USES THEREOF
    Publication number: 20240101505
    Abstract: This invention relates to Compound 1 (APX3330) salts and esters. The invention also provides compositions comprising a Compound 1 salt or ester. The invention also provides compounds of formula (I) and formula (II) and pharmaceutically acceptable salts thereof. The invention further provides compositions comprising a compound of formula (I) or formula (II), or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or vehicle. The invention also provides methods for treating or preventing a disease, such as cancer, a liver disorder, an ocular disorder, a cardiovascular disorder, fibrosis, or an inflammatory disorder, comprising administering to a subject in need thereof an effective amount of a Compound 1 salt or ester; or compound of formula (I) or formula (II), or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 28, 2024
    Inventors: Daniela Carmen ONICIU, Maria-Andreea LUNGAN, Andrei-Alunel PATRASCU, Corina-Mihaela MANTA, Anthony CARESTIA, Jon HOUSLEY
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20240092721
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Application
    Filed: June 1, 2023
    Publication date: March 21, 2024
    Applicant: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen ONICIU
  • LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF
    Publication number: 20240000887
    Abstract: The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
    Type: Application
    Filed: August 4, 2023
    Publication date: January 4, 2024
    Applicant: ABIONYX PHARMA SA
    Inventors: Jean-Louis DASSEUX, Rose ACKERMANN, Daniela Carmen ONICIU
  • LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF
    Publication number: 20230372441
    Abstract: The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 23, 2023
    Applicant: ABIONYX PHARMA SA
    Inventors: Jean-Louis DASSEUX, Rose ACKERMANN, Daniela Carmen ONICIU
  • Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease
    Patent number: 11737995
    Abstract: Methods for treating or preventing kidney diseases and fibrosis, such as chronic kidney disease (CKD), kidney fibrosis, heart fibrosis, uterine fibrosis, and cystic fibrosis, with compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: August 29, 2023
    Assignee: Espervita Therapeutics, Inc.
    Inventors: Daniela Carmen Oniciu, Gregory R. Steinberg, Spencer Heaton, Roger Schofield Newton, James Stuart Vincent Lally, Jaya Gautam
  • Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease
    Patent number: 11730712
    Abstract: This invention provides compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: August 22, 2023
    Assignee: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen Oniciu
  • HIGHLY PURE PHENTOLAMINE MESYLATE AND METHODS FOR MAKING SAME
    Publication number: 20230146674
    Abstract: This invention provides methods for synthesizing phentolamine mesylate from phentolamine and methanesulfonic acid in the presence of acetone and water. The methods of the present invention provide highly pure phentolamine mesylate. The invention also provides highly pure phentolamine mesylate.
    Type: Application
    Filed: December 30, 2022
    Publication date: May 11, 2023
    Inventor: Daniela Carmen ONICIU
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20230113853
    Abstract: This invention provides methods for treating or preventing kidney diseases and fibrosis, such as chronic kidney disease (CKD), kidney fibrosis, heart fibrosis, uterine fibrosis, and cystic fibrosis, with compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Application
    Filed: January 24, 2022
    Publication date: April 13, 2023
    Inventors: Daniela Carmen ONICIU, Gregory R. STEINBERG, Spencer HEATON, Roger Schofield NEWTON, James Stuart Vincent LALLY, Jaya GAUTAM
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20230111520
    Abstract: This invention provides compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Application
    Filed: January 24, 2022
    Publication date: April 13, 2023
    Inventor: Daniela Carmen Oniciu
  • Highly pure phentolamine mesylate and methods for making same
    Patent number: 11566005
    Abstract: This invention provides methods for synthesizing phentolamine mesylate from phentolamine and methanesulfonic acid in the presence of acetone and water. The methods of the present invention provide highly pure phentolamine mesylate. The invention also provides highly pure phentolamine mesylate.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: January 31, 2023
    Assignee: Ocuphire Pharma, Inc.
    Inventor: Daniela Carmen Oniciu
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20230007838
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof, and compositions thereof.
    Type: Application
    Filed: January 7, 2022
    Publication date: January 12, 2023
    Inventor: Daniela Carmen ONICIU
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20220402851
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof, and compositions thereof.
    Type: Application
    Filed: July 12, 2021
    Publication date: December 22, 2022
    Inventor: Daniela Carmen ONICIU
  • HIGHLY PURE PHENTOLAMINE MESYLATE AND METHODS FOR MAKING SAME
    Publication number: 20220388965
    Abstract: This invention provides methods for synthesizing phentolamine mesylate from phentolamine and methanesulfonic acid in the presence of acetone and water. The methods of the present invention provide highly pure phentolamine mesylate. The invention also provides highly pure phentolamine mesylate.
    Type: Application
    Filed: May 18, 2022
    Publication date: December 8, 2022
    Inventor: Daniela Carmen ONICIU
  • LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF
    Publication number: 20220362336
    Abstract: The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
    Type: Application
    Filed: May 27, 2022
    Publication date: November 17, 2022
    Applicant: ABIONYX PHARMA SA
    Inventors: Jean-Louis DASSEUX, Rose ACKERMANN, Daniela Carmen ONICIU
  • GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR
    Publication number: 20220332672
    Abstract: This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 ?m to about 90 ?m, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia.
    Type: Application
    Filed: January 24, 2022
    Publication date: October 20, 2022
    Inventors: Daniela Carmen ONICIU, Charles Larry BISGAIER, José Rui GOMES, Stefan HECKHOFF
  • Lipoprotein complexes and manufacturing and uses thereof
    Patent number: 11376309
    Abstract: The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: July 5, 2022
    Assignee: Cerenis Therapeutics Holding S.A.
    Inventors: Jean-Louis Dasseux, Rose Ackermann, Daniela Carmen Oniciu
  • Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease
    Patent number: 11267778
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 8, 2022
    Assignee: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen Oniciu
  • FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
    Publication number: 20210269384
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof, and compositions thereof.
    Type: Application
    Filed: April 26, 2021
    Publication date: September 2, 2021
    Inventor: Daniela Carmen ONICIU
  • Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease
    Patent number: 11098002
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: August 24, 2021
    Assignee: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen Oniciu
  • Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease
    Patent number: 11084773
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: August 10, 2021
    Assignee: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen Oniciu