Abstract: The invention relates to a dispenser 20 for the spray delivery of a preparation 18. The dispenser comprises: a reservoir 22 suitable for containing the preparation 18, a mechanical pump 24, a load chamber 26, a nozzle 28 having a delivery axis, and a delivery cone 30 having an axis. The mechanical pump is able, whenever operated: to take a predetermined amount of preparation from the reservoir, to supply said amount of preparation to the load chamber upstream of the nozzle, and to create a delivery pressure in the load chamber. The nozzle is able to deliver said amount of preparation in the form of an aerosol spray 180. The dispenser according to the invention is characterized in that the delivery cone comprises, in the proximity of the nozzle, at least one through-hole 320 suitable for putting the inside of the delivery cone into communication with the surrounding environment.

Abstract: The invention relates to a dispenser 20 for the spray delivery of a preparation 18. The dispenser comprises: a reservoir 22 suitable for containing the preparation 18, a mechanical pump 24, a load chamber 26, a nozzle 28 having a delivery axis, and a delivery cone 30 having an axis. The mechanical pump is able, whenever operated: to take a predetermined amount of preparation from the reservoir, to supply said amount of preparation to the load chamber upstream of the nozzle, and to create a delivery pressure in the load chamber. The nozzle is able to deliver said amount of preparation in the form of an aerosol spray 180. The dispenser according to the invention is characterized in that the delivery cone comprises, in the proximity of the nozzle, at least one through-hole 320 suitable for putting the inside of the delivery cone into communication with the surrounding environment.

Abstract: A topical antifungal composition for treating onychomycosis includes a terbinafine and/or a pharmaceutically acceptable salt thereof in an amount of from 9% to 11% by weight of the composition, a hydroxypropyl chitosan in an amount of from 0.1% to 0.6% by weight of the composition, water in an amount of from 10.0% to 40.0% by weight of the composition, and a C1-C4 alkanol in an amount of from 60% to 80% by weight of the composition.

Abstract: The present invention is directed to a nail lacquer consisting essentially of ciclopirox as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvent. The invention is also directed to such a nail lacquer for use in treating onychomycosis.

Abstract: The present invention is directed to a method to treat onychomycosis by topically administering a composition which contains hydroxypropyl chitosan as the sole active ingredient and, in particular, by administering a nail topical composition consisting essentially of: a) hydroxypropyl chitosan, b) water, c) at least a lower alkanol.

Abstract: The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Abstract: A nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents, including a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Abstract: The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Abstract: The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Abstract: Modified release oil in water emulsions that delivers drugs to a target tissue. The emulsions according to the present invention contain the lipophilic active ingredient completely dissolved into the hydrophobic internal phase stabilised by a polymeric surfactant. The presence of this polymer around the hydrophobic droplets avoids the migration of the active ingredient into the external hydrophilic phase and, consequently, its re-crystallization.