Patents by Inventor Daniela Delli Castelli

Daniela Delli Castelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS
    Publication number: 20190209713
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Application
    Filed: January 24, 2019
    Publication date: July 11, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Daniela DELLI CASTELLI, Franco FEDELI, Dario Livio LONGO, Enzo TERRENO, Fulvio UGGERI
  • CEST systems exhibiting a concentration independent responsiveness
    Patent number: 10328162
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 25, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • CEST systems exhibiting a concentration independent responsiveness
    Patent number: 10232060
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: March 19, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • Integrin targeted synthetic ligands for diagnostic and therapeutic applications
    Patent number: 9409951
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 9, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications
    Patent number: 8945512
    Abstract: Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: February 3, 2015
    Assignee: Bracco Imaging SpA
    Inventors: Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Giovanni Battista Giovenzana
  • INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20140178302
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Application
    Filed: January 13, 2014
    Publication date: June 26, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano LATTUADA, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • Integrin targeted synthetic ligands for diagnostic and therapeutic applications
    Patent number: 8636977
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: January 28, 2014
    Assignee: Bracco Imaging S.p.A.
    Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • MRI-CEST diagnostic technique based on non-punctual analysis
    Patent number: 8611981
    Abstract: An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: December 17, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Dario Livio Longo, Joseph Stancanello, Enzo Terreno, Fulvio Uggeri
  • CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS
    Publication number: 20130195768
    Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 1, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
  • Responsive paramagnetic MRI contrast agents
    Patent number: 8318134
    Abstract: A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: November 27, 2012
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Enzo Terreno
  • MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS
    Publication number: 20110152671
    Abstract: An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency.
    Type: Application
    Filed: August 18, 2009
    Publication date: June 23, 2011
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Dario Livio Longo, Joseph Stancanello, Enzo Terreno, Fulvio Uggeri
  • RESPONSIVE PARAMAGNETIC MRI CONTRAST AGENTS
    Publication number: 20090234221
    Abstract: A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
    Type: Application
    Filed: April 3, 2009
    Publication date: September 17, 2009
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Enzo Terreno
  • Responsive paramagnetic MRI contrast agents
    Patent number: 7524483
    Abstract: A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: April 28, 2009
    Assignee: Bracco Imaging S.p.A.
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Enzo Terreno
  • Integrin Targeted Synthetic Ligands for Diagnostic and Therapeutic Applications
    Publication number: 20080317668
    Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
    Type: Application
    Filed: March 3, 2006
    Publication date: December 25, 2008
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
  • Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "cest" applications
    Publication number: 20070036727
    Abstract: Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a para-magnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
    Type: Application
    Filed: April 6, 2004
    Publication date: February 15, 2007
    Inventors: Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Giovanni Giovenzana
  • Responsive paramagnetic mri contrast agents
    Publication number: 20050191243
    Abstract: A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
    Type: Application
    Filed: January 27, 2003
    Publication date: September 1, 2005
    Inventors: Silvio Aime, Daniela Delli Castelli, Franco Fedeli, Enzo Terreno