Abstract: A therapeutic agent delivery device has a texturized protective backing, preferably with three-dimensional surface features. By providing the drug delivery device with such a texturized backing, several advantageous properties are imparted to the device, e.g., enhanced ability to camouflage wrinkles and swelling, greater permeability of the backing to water vapor and oxygen, improved flexibility and conformability, and thus, enhanced comfort for the host wearing the device.