Abstract: Provided are high-throughput screens for biologically active modulators of a target enzyme that mimic or recreate natural processes of diversification and selection. In some embodiments, the platform comprises one or more expression systems including without limitation (i) a two-hybrid system that, when expressed in a cell, links survival of the cell to the modulation of a therapeutic target, and (ii) a metabolic system that enables the biosynthesis of structurally varied modulators of the therapeutic agent.

Abstract: The invention relates to an anode circuit (8) for a fuel cell (3) having at least one gas jet pump (6) for recirculating anode exhaust gas, which has at least one nozzle (18) through which the fuel gas (H 2) may flow as a fuel gas flow, and which has a fuel gas line (14), a recirculation line (7), and an outflow line (15). The anode circuit according to the invention is characterized in that a plurality of nozzles (18) with different geometries are arranged in a nozzle body (16), which is movable relative to the fuel gas line (14) in such a manner that in each case one of the nozzles (18) is selectively usable.

Abstract: The invention relates to a cooking oven comprising at least two entities made of sheet metal (2, 3), each sheet metal entity (2, 3) comprising at least one surface carrying an enamel layer, specifically a vitreous enamel layer, said enamelled sheet metal entities (2, 3) overlapping each other and a screw connection for grounding and coupling said enamelled sheet metal entities (2, 3), wherein a ground element is at least indirectly coupled with one of said enamelled sheet metal entities (2, 3) for grounding said stack of enamelled sheet metal entities (2, 3), wherein at least one screw (5) with a screw shaft (5.1) is provided through said enamelled sheet metal entities (2, 3), wherein the screw (5) is at least indirectly electrically coupled with the ground element and said screw shaft (5.1) comprises a thread for providing an electric coupling between the enamelled sheet metal entities (2, 3).

Abstract: A non-metallic gasket for flanged connections that is capable of achieving the necessary gasket stress to maintain a leak-free seal between the two flanges especially in applications when metallic gaskets cannot be used. The gasket may utilize glass reinforced epoxy, or rigid non-metallic material, as the gasket core. The core receives a kammprofile set of serrations machined into both faces. On top of the serrations a sealing element of varying material is adhered.

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside (s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: The invention relates to a cooking oven comprising at least two entities made of sheet metal (2, 3), each sheet metal entity (2, 3) comprising at least one surface carrying an enamel layer, specifically a vitreous enamel layer, said enamelled sheet metal entities (2, 3) overlapping each other and a screw connection for grounding and coupling said enamelled sheet metal entities (2, 3), wherein a ground element is at least indirectly coupled with one of said enamelled sheet metal entities (2, 3) for grounding said stack of enamelled sheet metal entities (2, 3), wherein at least one screw (5) with a screw shaft (5.1) is provided through said enamelled sheet metal entities (2, 3), wherein the screw (5) is at least indirectly electrically coupled with the ground element and said screw shaft (5.1) comprises a thread for providing an electric coupling between the enamelled sheet metal entities (2, 3).

Abstract: The present invention relates to a method for protecting a user of a light system (100), which comprises multiple illuminants (L1-L6), at least one light sensor (30) and at least one coding unit (40), from dazzling light from at least one of the illuminants (L1-L6), comprising the following steps: creating of a respective coding for light (M1-M6) of the individual illuminants (L1-L6) by the at least one coding unit (40), detecting of dazzling light (M2X) from at least one of the illuminants (L1-L6) by the at least one light sensor (30), assigning of the detected dazzling light (M2X) with the at least one associated illuminant (L2) on the basis of the coding of the light for the corresponding illuminant (L2), and setting of the at least one associated illuminant (L2) to protect the user from the detected dazzling light (M2X). The invention furthermore relates to a light system (100) and a machine (200) having the light system (100) for carrying out a method according to the invention.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside (s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside(s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: The present invention relates to a method for protecting a user of a light system (100), which comprises multiple illuminants (L1-L6), at least one light sensor (30) and at least one coding unit (40), from dazzling light from at least one of the illuminants (L1-L6), comprising the following steps: creating of a respective coding for light (M1-M6) of the individual illuminants (L1-L6) by the at least one coding unit (40), detecting of dazzling light (M2X) from at least one of the illuminants (L1-L6) by the at least one light sensor (30), assigning of the detected dazzling light (M2X) with the at least one associated illuminant (L2) on the basis of the coding of the light for the corresponding illuminant (L2), and setting of the at least one associated illuminant (L2) to protect the user from the detected dazzling light (M2X). The invention furthermore relates to a light system (100) and a machine (200) having the light system (100) for carrying out a method according to the invention.

Abstract: The invention relates to a screw connection comprising a structural element (2) comprising a screw hole (2.1) and a metal sheet (3) comprising a through hole (3.1), the structural element (2) and the metal sheet (3) being adapted to be connected by means of a screw (4) by screwing the screw (4) through the through hole (3.1) of the metal sheet (3) into the screw hole (2.1) of the structural element (2), wherein the metal sheet (3) comprises an embossment (5), said embossment (5) at least partially surrounding the through hole (3.1) in order to increase the distance (d) between an upper surface of the metal sheet (3) and the screw hole (2.1) provided in the structural element (2).

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: A network system uses the capabilities of client devices to search for objects in an image within a geographic region. The network system receives a request to search for an object and a geographic region within which to search the object. The network system provides instructions to client devices within the geographic region to search for the object. Upon receiving instructions to search for the object, the client device captures visual data of the area around the client device. The client device analyzes the visual data to detect the object and notifies the network system if the object is detected.

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: A domestic appliance (1), comprising a food probe (2) and a cord pullback mechanism (3), wherein the food probe (2) is for determining of at least one parameter within an interior space (4) of the domestic appliance (1), and wherein the food probe (2) is connectable to the domestic appliance (1) by a cord (5), and wherein the cord pullback mechanism (3) is for winding and dispensing the cord (5).

Abstract: In a washing element holder (2), which on one side is closed off relative to the outside(s) with a sponge material (5) having pores (4), a washing device (1) has a washing element (3) which has at least one synthetic surfactant as a foaming substance and the principal constituent.

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.

Abstract: The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.