Patents by Inventor Daniela Novick

Daniela Novick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for screening inhibitors of interleukin-32 (IL-32)
    Patent number: 9045559
    Abstract: The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: June 2, 2015
    Assignees: Yeda Research and Development Co. Ltd, The Regents of the University of Colorado
    Inventors: Daniela Novick, Menachem Rubinstein, Charles A. Dinarello, Soo-Hyun Kim
  • Antibodies against interleukin-18 binding protein, their preparation and use
    Patent number: 8436148
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: May 7, 2013
    Inventors: Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Daniela Novick
  • Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA
    Patent number: 8138323
    Abstract: An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: March 20, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Hartmut Engelmann, Dan Aderka, Daniela Novick, Menachem Rubinstein
  • METHODS OF TREATING/PREVENTING INFLAMMATION USING COMBINATION OF IL-1 ANTAGONIST AND IL-18 BINDING PROTEIN
    Publication number: 20110177065
    Abstract: The invention relates to the combined use of an IL-1 antagonist/inhibitor and IL-18 binding protein in inflammatory diseases.
    Type: Application
    Filed: February 15, 2011
    Publication date: July 21, 2011
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • IL-32 MODULATORS
    Publication number: 20110044999
    Abstract: The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.
    Type: Application
    Filed: October 8, 2010
    Publication date: February 24, 2011
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: DANIELA NOVICK, MENACHEM RUBINSTEIN, CHARLES A. DINARELLO, SOO-HYUN KIM
  • Promoter to IL-18BP, its preparation and use
    Patent number: 7868154
    Abstract: The present invention relates to the promoter of interleukin-18 binding protein (IL-18BP), to its preparation and use.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: January 11, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • INTERLEUKIN-18 BINDING PROTEINS, THEIR PREPARATION AND USE FOR THE TREATMENT OF SEPSIS
    Publication number: 20100254941
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Application
    Filed: March 1, 2010
    Publication date: October 7, 2010
    Applicant: Yeda Research Institute and Development Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Giamila Fantuzzi, Leonid L. Reznikov, Boris Schwartsburd
  • Interleukin-18 binding proteins, their preparation and use
    Patent number: 7799541
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: September 21, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
  • Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
    Patent number: 7704944
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: April 27, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Giamila Fantuzzi, Leonid L. Reznikov, Boris Schwartsburd
  • Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
    Patent number: 7696154
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: April 13, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Yolande Chvatchko, Christine Plater-Zyberk
  • INTERLEUKIN-18 BINDING PROTEINS, THEIR PREPARATION AND USE
    Publication number: 20100010200
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Application
    Filed: July 29, 2009
    Publication date: January 14, 2010
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
  • Il-32 Modulators
    Publication number: 20080267908
    Abstract: The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by-inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).
    Type: Application
    Filed: July 10, 2006
    Publication date: October 30, 2008
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Daniela Novick, Menachem Rubinstein, Charles A. Dinarello, Soo-Hyun Kim
  • Use of Il-18 Binding Protein in Inflammations
    Publication number: 20070264237
    Abstract: The invention relates to the combined use of an IL-1 antagonist/inhibitor and IL-18 binding protein in inflammatory diseases.
    Type: Application
    Filed: December 27, 2004
    Publication date: November 15, 2007
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • Interleukin-18 binding proteins, their preparation and use
    Publication number: 20070173439
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 26, 2007
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Kim, Yolande Chvatchko, Christine Plater-Zyberk
  • Interleukin-18 binding proteins, their preparation and use
    Patent number: 7220717
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: May 22, 2007
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Yolande Chvatchko, Christine Plater-Zyberk
  • Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
    Publication number: 20070081975
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Application
    Filed: August 16, 2006
    Publication date: April 12, 2007
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Kim, Giamila Fantuzzi, Leonid Reznikov, Boris Schwartsburd
  • Promoter to il-18bp, its preparation and use
    Publication number: 20060239984
    Abstract: The present invention relates to the promoter of interleukin-18 binding protein (IL-18BP), to its preparation and use.
    Type: Application
    Filed: October 9, 2003
    Publication date: October 26, 2006
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • Interleukin-18 binding proteins, their preparation and use
    Patent number: 7101689
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: September 5, 2006
    Assignee: Yeda Research and Development Company Limited
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
  • Preparation of biologically active molecules
    Patent number: 7098002
    Abstract: Biologically active molecules are produced from their biologically inactive precursors by mutation of their native cleavage site to a site which is capable of being cleaved by a protease, and cleavage of the mutated molecule to yield a biologically active molecule.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: August 29, 2006
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Menachem Rubinstein, Bianling Liu, Daniela Novick, Pierre Graber
  • Interleukin-18 binding proteins, their preparation and use
    Publication number: 20060154294
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Application
    Filed: March 15, 2006
    Publication date: July 13, 2006
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Kim