Patents by Inventor Daniela Palano

Daniela Palano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 3-glutamido bile ester derivatives using n-prtotected methyl proglutamate
    Publication number: 20040138185
    Abstract: The present invention relates to a novel process for the preparation of bile esters derivatives of general formula (1), in which R0 is H or OH; R1 is H, &agr;-OH or &bgr;-OH; R2 and R3 are independently hydrogen, straight or branched (C1-C20) alkyl optionally substituted with aryl; R5 is a straight or branched (C1-C4) alkyl and R6 is a straight or branched (C1-C4) alkyl or a benzyl group, via transamidation of the amine (V) with the 5-ocoproline derivative (II), wherein R4 is selected from the group consisting of tertbutoxycarbonyl, methoxycarbonyl, ethoxycarbonyl, 2-trimethylsilylethoxycarbonyl, cyclobutoxycarbonyl and 1-methylcyclobutoxy carbonyl, followed by the selective cleavage of the protecting group R4 under acidic conditions.
    Type: Application
    Filed: March 12, 2004
    Publication date: July 15, 2004
    Inventors: Marino Brocchetta, Pier Lucio Anelli, Giuseppe Manfredi, Massimo Visigalli, Daniela Palano, Laura Alessandroni
  • Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
    Patent number: 6461588
    Abstract: Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: October 8, 2002
    Assignee: Bracco Imaging S.p.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Christoph De Haen, Ornella Gazzotti, Luciano Lattuada, Giovanna Lux, Giuseppe Manfredi, Pierfrancesco Morosini, Daniela Palano, Michele Serleti, Fulvio Uggeri, Massimo Visigalli
  • Diagnostic imaging contrast agent with improved in serum relaxivity
    Patent number: 6458337
    Abstract: Compounds of the formula when chelated with metals exhibit improved serum relaxivity and are used in magnetic resonance imaging, particularly for imaging the blood pool.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: October 1, 2002
    Assignee: Dibra S.p.A
    Inventors: Pier Lucio Anelli, Marco Lolli, Franco Fedeli, Mario Virtuani, Marino Brocchetta, Pierfrancesco Morosini, Daniela Palano
  • Manganese chelates with high relaxivity in serum
    Patent number: 6337064
    Abstract: Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: January 8, 2002
    Assignee: Dibra S.p.A.
    Inventors: Marino Brocchetta, Luisella Calabi, Daniela Palano, Lino Paleari, Fulvio Uggeri