Patents by Inventor Daniela Pizzirani

Daniela Pizzirani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
    Publication number: 20240116947
    Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-? (TGF-?) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
    Type: Application
    Filed: July 14, 2021
    Publication date: April 11, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Daniele PALA, Daniela PIZZIRANI, Paolo BRUNO, Paolo RONCHI, Matteo BIAGETTI, Sara GUARIENTO, Claudio FIORELLI
  • PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
    Publication number: 20240116948
    Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-? (TGF-?) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 11, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Daniele PALA, Daniela PIZZIRANI, Paolo BRUNO, Matteo BIAGETTI, Paolo RONCHI, Sara GUARIENTO, Barbara BERTANI, Donatella RESCIGNO
  • AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS
    Publication number: 20240025880
    Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: November 26, 2021
    Publication date: January 25, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Claudio FIORELLI, Paolo BRUNO, Matteo BIAGETTI, Daniela PIZZIRANI, Daniele PALA, Paolo RONCHI, Sara GUARIENTO, Charles BAKER-GLENN, Hervé VAN DE POËL, Kim Louise HIRST
  • PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
    Publication number: 20240018122
    Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-? (TGF-?) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 18, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Daniela PIZZIRANI, Matteo BIAGETTI, Paolo RONCHI, Paolo BRUNO, Sara GUARIENTO, Barbara BERTANI, Daniele PALA, Alessio BARILLI
  • AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS
    Publication number: 20230092892
    Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: May 28, 2020
    Publication date: March 23, 2023
    Inventors: Paolo BRUNO, Matteo BIAGETTI, Claudio FIORELLI, Daniela PIZZIRANI, Daniele PALA, Paolo RONCHI, Charles BAKER-GLENN, Hervè VAN DE POËL, Kim Louise HIRST
  • AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS
    Publication number: 20220227749
    Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Inventors: Paolo BRUNO, Matteo BIAGETTI, Claudio FIORELLI, Daniela PIZZIRANI, Daniele PALA, Paolo RONCHI, Charles BAKER-GLENN, Hervè VAN DE POËL, Kim Louise HIRST, Sara GUARIENTO
  • Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    Patent number: 10226452
    Abstract: The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: March 12, 2019
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Tecnologia
    Inventors: Daniele Piomelli, Chiara Pagliuca, Daniela Pizzirani, Anders Bach, Natalia Realini, Marco De Vivo
  • Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    Patent number: 10213416
    Abstract: The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: February 26, 2019
    Assignees: The Regents of the University of Chicago, Fondazione Istituto Italiano di Technologia
    Inventors: Daniele Piomelli, Daniela Pizzirani, Anders Bach, Rita Scarpelli, Laurin Melzig, Marco Mor
  • Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease
    Patent number: 9975861
    Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 22, 2018
    Assignees: FONDAZIONE ISTITUTO ITAIANO DI TECNOLOGIA, ALMA MATER STUDIORUM—UNIVERSITA'DI BOLOGNA
    Inventors: Andrea Cavalli, Federica Prati, Giovanni Bottegoni, Angelo Danilo Favia, Daniela Pizzirani, Rita Scarpelli, Maria Laura Bolognesi
  • SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
    Publication number: 20170182009
    Abstract: The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Application
    Filed: November 8, 2016
    Publication date: June 29, 2017
    Inventors: Daniele PIOMELLI, Daniela PIZZIRANI, Anders BACH, Rita SCARPELLI, Laurin MELZIG, Marco MOR
  • BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
    Publication number: 20170182010
    Abstract: The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Application
    Filed: November 8, 2016
    Publication date: June 29, 2017
    Inventors: Daniele PIOMELLI, Chiara PAGLIUCA, Daniela PIZZIRANI, Anders BACH, Natalia REALINI, Marco DE VIVO
  • Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease
    Publication number: 20170096406
    Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 6, 2017
    Inventors: Andrea Cavalli, Federica Prati, Giovanni Bottegoni, Angelo Danilo Favia, Daniela Pizzirani, Rita Scarpelli, Maria Laura Bolognesi
  • Acid ceramidase inhibitors and their use as medicaments
    Patent number: 9428465
    Abstract: The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: August 30, 2016
    Assignee: Fondazione Istituto Italiano Di Technologia
    Inventors: Daniele Piomelli, Natalia Realini, Marco Mor, Chiara Pagliuca, Daniela Pizzirani, Rita Scarpelli, Tiziano Bandiera
  • ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS
    Publication number: 20150111892
    Abstract: The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
    Type: Application
    Filed: May 27, 2013
    Publication date: April 23, 2015
    Inventors: Daniele Piomelli, Natalia Realini, Marco Mor, Chiara Pagliuca, Daniela Pizzirani, Rita Scarpelli, Tiziano Bandiera