Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: The invention provides a dynamic risk analyzer (DRA) that periodically assesses real-time or historic process data, or both, associated with an operations site, such as a manufacturing, production, or processing facility, including a plant's operations, and identifies hidden near-misses of such operation, when in real time the process data appears otherwise normal. DRA assesses the process data in a manner that enables operating personnel including management at a facility to have a comprehensive understanding of the risk status and changes in both alarm and non-alarm based process variables. The hidden process near-miss data may be analyzed alone or in combination with other process data and/or data resulting from prior near-miss situations to permit strategic action to be taken to reduce or avert the occurrence of adverse incidents or catastrophic failure of a facility operation.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: The present invention relates to a mold for molding a component, in particular a particle foam part and a method for manufacturing the component using such a mold. In one embodiment, a mold for molding a component comprises (a.) a mixture of a polymer material and a filler material, (b.) wherein the filler material is adapted to allow a heating of the component inside the mold by means of an electromagnetic field.

Abstract: A vehicle includes a battery housing, a plurality of batteries, and a door step. The battery housing is disposed in a floor area of the vehicle. The batteries are within the battery housing. The door step is located proximate a side of the battery housing. The door step includes an upper running board with a stepping surface and a lower bottom part that is spaced apart from the upper running board and extends parallel to the upper running board to define at least one chamber therebetween. The lower bottom part includes a central weakened area which extends in a longitudinal direction of the vehicle and is configured to permit a center region of the door step to buckle upwards in response to a lateral force greater than a predetermined threshold amount of force.

Abstract: A dynamic control valve assembly for use in filling a liquid carbon dioxide storage and gas delivery system is provided, the assembly comprising: a valve body; an end nut with an inlet port for receiving liquid carbon dioxide; a chamber; an inlet cavity; a liquid port; a gas port; and a dynamic compound valve stem assembly for blocking the gas port while liquid carbon dioxide is delivered through the inlet port and allowing the liquid carbon dioxide to flow through the liquid port for storage in a liquid cylinder, and open the gas port and block the inlet port in order to allow carbon dioxide gasses from boiling liquid carbon dioxide within the liquid cylinder to pass through the gas port for storage in a gas cylinder until system pressure and temperature equilibrium is reached. The dynamic compound valve stem assembly comprises: a stem body having an inlet port poppet and a gas port poppet; an inlet cavity collar; and in some embodiments a collar biasing spring.

Abstract: To enable fast beam tracking and/or low latency a first communication device comprising a sensing circuitry configured to sense motion of the first communication device and to generate motion information representing the sensed motion, the motion information comprising rotation information indicating rotation and/or orientation of the first communication device, and a communication circuitry configured to transmit the motion information to a second communication device within a layer of a hierarchical layer model lower than a transport layer. A second communication device comprises a communication circuitry configured to receive motion information from a first communication device within a layer of a hierarchical layer model lower than a transport layer.

Abstract: An injection device kit for the self-administration of an injection of solution that includes a body portion configured for engagement with a cartridge containing the solution and an injection needle where the body portion includes an injection component having an actuation mechanism for inserting the injection needle of the cartridge and for injecting the solution in the cartridge and a safety mechanism on the body portion and configured to prevent injection unless released.

Abstract: A fluid damping apparatus includes a housing enclosing a chamber retaining a damping fluid, a piston disposed in the housing chamber and movable between a first end position and a second end position, and a variable volume element disposed in the housing chamber having a first size occupying a first volume in the housing chamber. Increased fluid pressure of the damping fluid (e.g., resulting from increased temperature of the fluid damping apparatus and associated expansion of the damping fluid) compresses the variable volume element to a second size occupying a second volume in the housing chamber smaller than the first volume, to permit expansion of the damping fluid, thereby limiting fluid pressure of the damping fluid.

Abstract: A mobile CO2 filling system selectively fills onsite CO2 storage and dispensing systems with CO2. The system includes a mobile platform; a tank holding liquid CO2 mounted on the mobile platform; a flexible dispensing hose couple to the tank and configured to be selectively coupled to the filling inlet of an onsite CO2 storage and dispensing system; a pump selectively coupled to the tank; and a controller for controlling the filling of an onsite CO2 storage and dispensing systems with CO2 from the tank, wherein the controller is selectively designated by the user to operate in at least one pump assisted filling state and at least one gravity feed filling state.

Abstract: The invention is directed to a toughener for epoxy adhesives, the toughener being a reaction product of a bisphenolic blocked PU toughener with a diglycidyl ether-bisphenol product such as liquid DGEBA. The invention includes adhesives comprising the inventive tougheners, methods of using the tougheners and adhesives comprising them, as well as cured inventive adhesives and products comprising them.

Abstract: A system and method for providing remote video communications, and more specifically, a system and method for providing multi-point-of-view video chatting for a group of participants is disclosed. The client device having a microphone, a video capture device having speakers, a display device, a memory having instructions stored thereon, and a processor configured to execute the instructions on the memory to cause the electronic client device to implement the method.

Abstract: An epoxy-based crash durable adhesive composition including: (I) a liquid resin system comprising: (a) at least one epoxy resin; and (b) at least one toughener; wherein the viscosity of the above liquid resin system is less than about 800 Pa s at a temperature of 15° C.; and wherein the viscosity of the above liquid resin system is greater than about 5 Pa-s at a temperature of 60° C.; (II) a solid material comprising: (c) at least one hydrophobic fumed silica, wherein the fumed silica is present in the adhesive composition at a concentration of greater than 5 weight percent; and (III) a curative material comprising: (d) at least one latent heat-activated curing agent; wherein the rheology of the epoxy-based crash durable adhesive composition is such that the adhesive composition is pumpable at a temperature of 15° C.

Abstract: A dynamic control valve assembly for use in filling a liquid carbon dioxide storage and gas delivery system is provided, the assembly comprising: a valve body; an end nut with an inlet port for receiving liquid carbon dioxide; a chamber; an inlet cavity; a liquid port; a gas port; and a dynamic compound valve stem assembly for blocking the gas port while liquid carbon dioxide is delivered through the inlet port and allowing the liquid carbon dioxide to flow through the liquid port for storage in a liquid cylinder, and open the gas port and block the inlet port in order to allow carbon dioxide gasses from boiling liquid carbon dioxide within the liquid cylinder to pass through the gas port for storage in a gas cylinder until system pressure and temperature equilibrium is reached. The dynamic compound valve stem assembly comprises: a stem body having an inlet port poppet and a gas port poppet; an inlet cavity collar; and in some embodiments a collar biasing spring.

Abstract: The disclosed subject matter relates to an apparatus for simulating motion, comprising: a base; a seat with a seat pan and seat back, the seat having a roll axis and, orthogonal thereto, a pitch axis; a mount mounting the seat to the base at least pivotably about said roll axis and said pitch axis; a left seat back flap and a right seat back flap each of which being pivotably attached to a respective side of the seat back; and a linkage linking said seat back flaps to the base so that, when any one of the sides of the seat back is moved towards the base, the respective seat back flap is pivoted inwards and, when said side of the seat back is moved away from the base, said seat back flap is pivoted outwards.

Abstract: A mobile CO2 filling system selectively fills onsite CO2 storage and dispensing systems with CO2. The system includes a mobile platform; a tank holding liquid CO2 mounted on the mobile platform; a flexible dispensing hose couple to the tank and configured to be selectively coupled to the filling inlet of an onsite CO2 storage and dispensing system; a pump selectively coupled to the tank; and a controller for controlling the filling of an onsite CO2 storage and dispensing systems with CO2 from the tank, wherein the controller is selectively designated by the user to operate in at least one pump assisted filling state and at least one gravity feed filling state.

Abstract: Polynucleotides, such as aptamers, comprising at least first one 5-position modified pyrimidine and at least one second 5-position modified pyrimidine are provided, wherein the first and second 5-position modified pyrimidines are different. Methods of selecting and using such polynucleotides, such as aptamers, are also provided.

Abstract: Various embodiments of the teachings herein include a method for onboarding an IoT device (3) of a manufacturer, in a manner secure against quantum computer attacks, in an infrastructure of a customer by means of a first server (1) of a manufacturer domain of the manufacturer and a second server (2) of a customer domain of the customer. In some embodiments, three authenticated and encrypted communication channels and a key encapsulation method are used to provide a device certificate of the customer domain for the IoT device on the IoT device.

Abstract: A system and method for providing non-binary profile mapping of individuals according to the present invention is disclosed. The system includes a memory having instructions stored thereon and a processor configured to execute the instructions on the memory to cause the electronic apparatus to perform the method. The method receives user profile data from an external user, the user profile data comprises captured media having a user image and user characteristic information data, pre-processes a user image into training, testing, and updating learning networks, stores processed user profile data into a database, receive user synthetic profile data to create a synthetic profile representation, adjust the synthetic profile representation in response to user input, generates a first set of matching results from processing the synthetic profile representation against user profile data from the database using the learning networks, and provides the first set of matching results for selection.

Abstract: The following relates to a hardware security module for usage with manufacturing devices and a method for operating the same is provided. The security module includes: a secure element, which is adapted to detect an operating mode of the hardware security module; a first interface which is adapted to receive commands for controlling the hardware security module; a central processing unit for processing application program code in a secure environment; a second interface which is adapted for receiving configuration data, wherein the second interface is activated and deactivated in dependence of the detected operating mode.