Patents by Inventor Daniela Tropea

Daniela Tropea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFYING AND MODULATING MOLECULAR PATHWAYS THAT MEDIATE NERVOUS SYSTEM PLASTICITY
    Publication number: 20150174212
    Abstract: The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (DR) or monocular deprivation (MD). The genes are targets for pharmacological agents that modify plasticity. The invention also identifies biological pathways that are enriched in genes that are differentially regulated under conditions known to result in altered nervous system plasticity. The present invention further provides methods and compositions for modifying plasticity in the nervous system of a subject.
    Type: Application
    Filed: March 2, 2015
    Publication date: June 25, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Mriganka Sur, Daniela Tropea, Gabriel Kreiman
  • Identifying and modulating molecular pathways that mediate nervous system plasticity
    Patent number: 8969295
    Abstract: The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (DR) or monocular deprivation (MD). The genes are targets for pharmacological agents that modify plasticity. The invention also identifies biological pathways that are enriched in genes that are differentially regulated under conditions known to result in altered nervous system plasticity. The present invention further provides methods and compositions for modifying plasticity in the nervous system of a subject.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: March 3, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Mriganka Sur, Daniela Tropea, Gabriel Kreiman
  • TREATMENT OF RETT SYNDROME AND OTHER DISORDERS
    Publication number: 20120177630
    Abstract: The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules.
    Type: Application
    Filed: August 8, 2011
    Publication date: July 12, 2012
    Applicants: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Mriganka Sur, Daniela Tropea, Emanuela Giacometti, Rudolf Jaenisch, Nathan R. Wilson
  • Treatment of rett syndrome
    Patent number: 7994127
    Abstract: The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: August 9, 2011
    Assignees: Massachusetts Institute of Technology, Whitehead Institute of Biomedical Research
    Inventors: Mriganka Sur, Daniela Tropea, Emanuela Giacometti, Rudolf Jaenisch, Nathan R. Wilson
  • Identifying and Modulating Molecular Pathways that Mediate Nervous System Plasticity
    Publication number: 20090297573
    Abstract: The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (DR) or monocular deprivation (MD). The genes are targets for pharmacological agents that modify plasticity. The invention also identifies biological pathways that are enriched in genes that are differentially regulated under conditions known to result in altered nervous system plasticity. The present invention further provides methods and compositions for modifying plasticity in the nervous system of a subject.
    Type: Application
    Filed: April 12, 2007
    Publication date: December 3, 2009
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Mriganka Sur, Daniela Tropea, Gabriel Kreiman
  • TREATMENT OF RETT SYNDROME AND OTHER DISORDERS
    Publication number: 20090099077
    Abstract: The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules.
    Type: Application
    Filed: June 6, 2008
    Publication date: April 16, 2009
    Inventors: Mriganka Sur, Daniela Tropea, Emanuela Giacometti, Rudolf Jaenisch, Nathan R. Wilson