Patents by Inventor Daniela Verthelyi

Daniela Verthelyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
    Patent number: 9809824
    Abstract: The present invention provides a CpG oligonucleotide prodrug that includes a thermolabile substituent on at least one nucleotide thereof. The present invention also provides compositions that include a carrier and a therapeutically effective amount of at least one CpG oligonucleotide prodrug. The present invention further provides therapeutic methods of using such thermolabile CpG oligonucleotide prodrugs and compositions thereof. The present invention further provides a method of inhibiting tetrad formation in a CpG oligonucleotide by functionalizing the CpG oligonucleotide with one or more thermolabile substituents.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: November 7, 2017
    Assignee: The United States of America, Represented by the Secretary, Department of Health and Human Services
    Inventors: Daniela Verthelyi, Serge L. Beaucage, Andrzej Grajkowski
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 9163244
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: October 20, 2015
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 8741869
    Abstract: A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5? N1N2N3T-CpG-WN4N5N6 3? wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5? RY-CpG-RY 3? wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: June 3, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Uniformed Services University of the Health Sciences, an institution of higher learning within the Department of Defense
    Inventors: Dennis M. Klinman, Ken J. Ishii, Daniela Verthelyi, James J. Mond
  • SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20140134233
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: September 13, 2013
    Publication date: May 15, 2014
    Applicant: The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 8580944
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: November 12, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Method of treating inflammatory arthropathies with supressors of CPG oligonucleotides
    Patent number: 8557789
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 15, 2013
    Assignee: The United States of America as represented by the Secretary of the Development of Health and Human Services
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
    Patent number: 8481055
    Abstract: The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 9, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Bruce Ivins, Daniela Verthelyi
  • Olioodeoxynucleotide and its use to induce an immune response
    Patent number: 8389495
    Abstract: A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5?N1N2N3T-CpG-WN4N5N63? wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5?RY-CpG-RY3? wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: March 5, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Ken Ishii, Daniela Verthelyi, James J. Mond
  • METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES
    Publication number: 20130018089
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
    Patent number: 8288359
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: October 16, 2012
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20120258144
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: June 21, 2012
    Publication date: October 11, 2012
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
    Patent number: 8263091
    Abstract: A method is disclosed herein for increasing an immune response to an opportunistic infection in an immunocompromised subject. In one embodiment, the subject is infected with a lentivirus. The method includes increasing an immune response to a pathogen using D oligodeoxynucleotides including a CpG motif.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: September 11, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Daniela Verthelyi
  • Multiple CpG oligodeoxynucleotide and their use to induce an immune response
    Patent number: 8232259
    Abstract: Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in inducing an immune response in a large percentage of the individuals in a population.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: July 31, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Ken Ishii, Daniela Verthelyi
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 8227438
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: July 24, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 8227446
    Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5?X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: July 24, 2012
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
  • OLIOODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE
    Publication number: 20110313031
    Abstract: A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5?N1N2N3T-CpG-WN4N5N63? wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula: 5?RY—CpG-RY3? wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 22, 2011
    Inventors: Dennis Klinman, Ken Ishii, Daniela Verthelyi, James J. Mond
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 8030285
    Abstract: The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5?N1N2N3T-CpG-WN4N5N63? wherein the central CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any nucleotides, or the formula: 5?RY-CpG-RY3? wherein the central CpG motif is unmethylated, R is. A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: October 4, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis Klinman, Ken Ishii, Daniela Verthelyi, James J. Mond
  • OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE
    Publication number: 20110212135
    Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5?X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
    Type: Application
    Filed: May 10, 2011
    Publication date: September 1, 2011
    Applicant: The Gov't of USA as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
  • METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES
    Publication number: 20110201676
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • MULTIPLE CpG OLIGODEOXYNUCLEOTIDE AND THEIR USE TO INDUCE AN IMMUNE RESPONSE
    Publication number: 20110189267
    Abstract: Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in inducing an immune response in a large percentage of the individuals in a population.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 4, 2011
    Inventors: Dennis Klinman, Ken Ishii, Daniela Verthelyi