Patents by Inventor Daniele De Zani

Daniele De Zani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF STERILE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20210145836
    Abstract: The invention refers to a process for preparing sterile active pharmaceutical ingredients (APIs) useful in the preparation of sterile product for ophthalmic use. The process comprises the gamma-ray sterilization treatment of the APIs powder in a protective atmosphere.
    Type: Application
    Filed: January 26, 2021
    Publication date: May 20, 2021
    Applicant: ICROM SPA
    Inventors: Daniele De Zani, Aline Sassi, Pierfrancesco Morosini
  • Process for the preparation of bazedoxifene
    Patent number: 10844047
    Abstract: The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: November 24, 2020
    Assignee: ERREGIERRE S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Stefano Vezzosi, Paolo Belotti
  • PROCESS FOR THE PREPARATION OF BAZEDOXIFENE
    Publication number: 20190389842
    Abstract: The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Applicant: ERREGIERRE S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Stefano Vezzosi, Paolo Belotti
  • Process for the preparation of toltrazuril and an intermediate useful for its preparation
    Patent number: 9802906
    Abstract: Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N?-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 31, 2017
    Assignee: ERREGIERRE S.P.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • PROCESS FOR THE PREPARATION OF TOLTRAZURIL AND AN INTERMEDIATE USEFUL FOR ITS PREPARATION
    Publication number: 20170291880
    Abstract: Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N?-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 12, 2017
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Process for preparing vilazodone hydrochloride
    Patent number: 8802851
    Abstract: The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: August 12, 2014
    Assignee: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • PROCESS FOR PREPARING VILAZODONE HYDROCHLORIDE
    Publication number: 20140163227
    Abstract: The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
    Type: Application
    Filed: April 2, 2013
    Publication date: June 12, 2014
    Applicant: Erregierre S.p.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • Alkaloid ester and carbamate derivatives and medicinal compositions thereof
    Patent number: 8604015
    Abstract: Compounds according to formula (I) are effective for the treatment of broncho-obstructive and inflammatory diseases.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: December 10, 2013
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele Amari, Mauro Riccaboni, Daniele De Zani
  • PROCESS FOR PREPARING VILAZODONE HYDROCHLORIDE
    Publication number: 20130225818
    Abstract: The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
    Type: Application
    Filed: April 2, 2013
    Publication date: August 29, 2013
    Applicant: ERREGIERRE S.P.A.
    Inventors: Massimo Ferrari, Daniele De Zani, Matteo Bonaldi
  • ALKALOID ESTER AND CARBAMATE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF
    Publication number: 20120276018
    Abstract: Compounds according to formula (I) are effective for the treatment of broncho-obstructive and inflammatory diseases.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele AMARI, Mauro Riccaboni, Daniele De Zani