Abstract: The present invention generally relates to the controlled administration of substances through infusion devices implanted in the human body and more particularly has as an object an improved system for the controlled administration of a substance such as a drug, a hormone or a hormone complex and the like for which other administration modes result unsatisfactory or ineffective. More specifically, the invention is directed to such a system having an implanted infusion device provided with an improved docking group for reliably docking an ingestible substance carrier. The invention also relates to a special construction of the carrier.

Abstract: A device for endoscopically delivering therapeutic substance includes a cannula defining at least one extrusion channel and comprises a proximal portion, a flexible distal portion having an extrusion mouth, and a substantially rigid intermediate portion between the flexible distal portion and the proximal portion. The proximal portion is configured to feed and push a therapeutic substance into the extrusion channel, so that the latter can pass through the extrusion channel flowing through the intermediate portion and through the flexible distal portion and can exit from the extrusion mouth. The device also comprises at least one actuation cable having a proximal end operable at the proximal portion and a distal end connected to the flexible distal portion at the extrusion mouth, and configured to pull the flexible distal portion with a force transversal to the extrusion channel, bringing the flexible distal portion from an undeformed conformation to a deformed conformation.