Patents by Inventor Daniele Leonard

Daniele Leonard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase
    Patent number: 6008372
    Abstract: Substituted histidine compounds of formula (I) are described as well as methods for the preparation and pharamaceutical compositions of same, which are useful as inhibitors of protein famesyltransferase and for the treatment of proliferative diseases including cancer, restenosis, and psoriasis, and as antiviral agents.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: December 28, 1999
    Assignee: Warner-Lambert Company
    Inventors: Annette M. Doherty, James S. Kaltenbronn, Daniele Leonard, John Quin, III, Jeffrey D. Scholten
  • Quinazolines as inhibitors of endothelin converting enzyme
    Patent number: 5773444
    Abstract: Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: June 30, 1998
    Assignee: Warner-Lambert Company
    Inventors: Kyunghye Ahn, Xue-Min Cheng, Annette Marian Doherty, Edward Faith Elslager, Brian Kornberg, Chitase Lee, Daniele Leonard, Sham Nikam, Leslie Morton Werbel
  • Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
    Patent number: 5763577
    Abstract: Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Alfred Campbell, Richard Gowan, John Cooke Hodges, Donald Hupe, Daniele Leonard, Tomi Sawyer, Judith Sebolt-Leopold, Francis J. Tinney
  • Quinazolines as inhibitors of endothelin converting enzyme
    Patent number: 5658902
    Abstract: Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: August 19, 1997
    Assignee: Warner-Lambert Company
    Inventors: Kyunghye Ahn, Xue-Min Cheng, Annette Marian Doherty, Edward Faith Elslager, Brian Kornberg, Chitase Lee, Daniele Leonard, Sham Nikam, Leslie Morton Werbel