Patents by Inventor Daniele Marie Leonard

Daniele Marie Leonard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted tetralones as inhibitors of ras farnesyl transferase
    Patent number: 6943183
    Abstract: The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: September 13, 2005
    Assignee: Pfizer Inc
    Inventors: William Alexander Denny, Richard H. Hutchings, Douglas S. Johnson, James Stanley Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
  • Dihydro-2H-naphthalene-1-one inhibitors of ras farnesyl transferase
    Publication number: 20040171844
    Abstract: Disclosed are compounds of the Formula I 1
    Type: Application
    Filed: February 19, 2004
    Publication date: September 2, 2004
    Inventors: Daniele Marie Leonard, Joseph Thomas Repine, Gordon William Rewcastle
  • Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
    Publication number: 20040167131
    Abstract: This invention discloses amino acid derivatives which display inhibitory effects on the serine protease factor Xa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, methods for the preparation of the compounds, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Application
    Filed: September 11, 2003
    Publication date: August 26, 2004
    Applicant: Pfizer Inc.
    Inventors: Gary Louis Bolton, Kevin James Filipski, Jeffrey Thomas Kohrt, Frances La, Daniele Marie Leonard
  • Inhibitors of protein farnesyl transferase
    Patent number: 6737410
    Abstract: The present invention provides compounds having the structure represented by Formula I: and methods of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of Formula I and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: May 18, 2004
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, Daniele Marie Leonard, Dennis Joseph McNamara, Kevon Ray Shuler
  • 5- substituted tetralones as inhibitors of ras farnesyl trransferase
    Publication number: 20040044057
    Abstract: The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
    Type: Application
    Filed: May 19, 2003
    Publication date: March 4, 2004
    Inventors: William Alexander Denny, Richard H Hutchings, Douglas S Johnson, James Stanely Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
  • Dihydro-2h-napthalene-1-one inhibitors of ras farnesyl transferase
    Publication number: 20030232790
    Abstract: The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
    Type: Application
    Filed: October 8, 2002
    Publication date: December 18, 2003
    Inventors: Daniele Marie Leonard, Joseph Thomas Repine, Gordon William Rewcastle
  • Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
    Patent number: 6369034
    Abstract: The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: April 9, 2002
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, James Stanley Kaltenbronn, Daniele Marie Leonard, Dennis Joseph McNamara, John Quin, III
  • Dipeptide inhibitors of protein farnesyltransferase
    Patent number: 6265382
    Abstract: The present invention provides compounds having the structure represented by formula (I). Also provided is a method of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of formula (I).
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: July 24, 2001
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, Daniele Marie Leonard, Dennis Joseph McNamara, Kevon Ray Shuler
  • Benzopyranone and quinolone inhibitors of ras farnesyl transferase
    Patent number: 6143766
    Abstract: The present invention provides ras farnesyl transferase inhibiting compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: November 7, 2000
    Assignee: Warner-Lambert Company
    Inventors: James Stanley Kaltenbronn, Daniele Marie Leonard, Joseph Thomas Repine