Abstract: New immunostimulant substances are obtained by hydrolysing delipidized bovine casein with a proteolytic enzyme and fractionating the product.

Abstract: New immunostimulant substances are obtained by hydrolysing delipidized bovine casein with a proteolytic enzyme and fractionating the product.

Abstract: Tripeptides composed of the amino acids glycine, leucine, and phenylalanine or tyrosine obtainable by fractionation of hydrolysis products of human casein or by direct synthesis can be used as immunostimulants.

Abstract: New immunostimulant substances are obtained by hydrolyzing reduced and alkylated bovine fibrinogen with a proteolytic enzyme and fractionating the product.

Abstract: The hexapeptide of formulaVal-Glu-Pro-Ile-Pro-Tyr (I)which can be isolated from the hydrolysis products of human casein or synthesized from the amino acid residues which it contains, has immunological properties.

Abstract: New biologically active substances obtained by treating human casein with trypsin then fractionating and optionally purifying. They have immunological properties.

Abstract: The invention relates to novel water-soluble compounds, process for their preparation, methods of therapeutic treatment therewith and pharmaceutical compositions containing them. The compounds correspond to the formulae (III) and (IV) below or their mixtures in molar proportions of about 4/1, in which formulae X represents a RCO radical and Y represents a hydrogen atom or a RCO radical, or again in which Y represents a RCO radical and X represents a hydrogen atom or a RCO radical, R being an alkyl or alkenyl radical containing 11 to 19 carbon atoms in a straight or branched chain. ##STR1## The compounds are useful as immunological adjuvants.

Abstract: Novel derivatives with immunological activity are obtained by reacting a hydrosoluble extract of mycobacteria with an aliphatic acid derivative containing 10 to 18 carbon atoms and isolating the resulting product. The hydrosoluble extract of mycobacteria is a tetrasaccharide-heptapeptide or its dimer, trimer or tetramer possibly associated with non-amino reducing sugars. The derivative has the formula: ##STR1## IN WHICH M IS A WHOLE NUMBER COMPRISED BETWEEN 1 AND 4 INCLUSIVE, N IS A WHOLE NUMBER AT LEAST EQUAL TO 1 AND R is an alkyl radical containing 9 to 17 carbon atoms.

Abstract: There is disclosed a process for obtaining acetylated watersoluble extracts of corynebacteria and specifically of Corynebacterium parvum, of low molecular weight. Said process comprises acetylating delipidated bacterial residues of bacteria cells and isolating the watersoluble extracts by physico-chemical means. Said extracts are useful as immunological adjuvants in veterinary and human therapy.

Abstract: Watersoluble extracts of corynebacteria cells are obtained by a process which comprises the steps of subjecting bacterial residues of corynebacteria containing diaminopimelic acid, e.g. Corynebacterium parvum cells, to a mild extraction and of isolating the watersoluble extracts so obtained by physico-chemical methods. Said extracts are useful as immunological adjuvants.

Abstract: Hydrosoluble extracts of mycobacteria suitable as immunological adjuvants are prepared. These extracts have a molecular weight between 3,500 and 30,000 and adjuvant, non-arthrogenic properties. The delipidated bacterial residues of mycobacteria are subjected to a mild extraction, then the so-obtained substance is isolated and purified by physicochemical methods, or the delipidated bacterial residues of mycobacteria are treated by means of pyridine optionally in the presence of acetic anhydride, then the obtained products are treated with ethanol or water, and the hydrosoluble substances are isolated and purified by physicochemical methods.

Abstract: Hydrosoluble extracts of mycobacteria suitable as immunological adjuvants are prepared. These extracts have a molecular weight between 3,500 and 30,000 and adjuvant, non-arthrogen properties. The delipidated bacterial residues of mycobacteria are subjected to a mild extraction, then the so-obtained substance is isolated and purified by physicochemical methods, or the delipidated bacterial residues of mycobacteria are treated by means of pyridine, optionally in the presence of acetic anhydride, then the obtained products are treated with ethanol or water, and the hydrosoluble substances are isolated and purified by physicochemical methods.