Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-? (TGF-?) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.

Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-? (TGF-?) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.

Abstract: An embodiment of a 4D data ultrasound imaging system includes a matrix of transducer elements suitable for transmitting and for receiving ultrasound signals, said transducer elements being divided into sub-matrixes suitable for receiving in a delayed way a same acoustic signal, a plurality of reception channels with one of said reception channels being associated with one of said transducer elements, a beamformer device including a plurality of storage cells arranged in re-phasing matrixes, each re-phasing matrix being associated with a corresponding sub-matrix with each row associated with one of said transducer elements, said storage cells including an input storage stage that is selectively associated with a row and a reading output stage that is selectively associated with a buffer; each storage cell that belongs to a same column has the input stage that is dynamically activated in sequential times with respect to another storage cell of the same column for storing the same delayed acoustic signal, said s

Abstract: An embodiment of a 4D data ultrasound imaging system includes a matrix of transducer elements suitable for transmitting and for receiving ultrasound signals, said transducer elements being divided into sub-matrixes suitable for receiving in a delayed way a same acoustic signal, a plurality of reception channels with one of said reception channels being associated with one of said transducer elements, a beamformer device including a plurality of storage cells arranged in re-phasing matrixes, each re-phasing matrix being associated with a corresponding sub-matrix with each row associated with one of said transducer elements, said storage cells including an input storage stage that is selectively associated with a row and a reading output stage that is selectively associated with a buffer; each storage cell that belongs to a same column has the input stage that is dynamically activated in sequential times with respect to another storage cell of the same column for storing the same delayed acoustic signal, said s

Abstract: The disclosure relates to a driving method for obtaining a linear gain variation of a transconductance amplifier that includes a first differential transistor cell, with adjustment of a driving voltage value of a degenerative driving transistor of the transconductance amplifier The method includes generating an output current signal of a second differential cell corresponding to the first differential transistor cell of the transconductance amplifier, the output current signal having a linear relationship with a transconductance value of the second differential cell as the driving voltage varies; generating a reference current signal having a linear relationship with a differential input voltage; comparing the output current signal and the reference current signal for adjusting the driving voltage value; and modifying the transconductance value of the second differential cell up to a balance of the current signals.

Abstract: The disclosure relates to a driving method for obtaining a linear gain variation of a transconductance amplifier that includes a first differential transistor cell, with adjustment of a driving voltage value of a degenerative driving transistor of the transconductance amplifier The method includes generating an output current signal of a second differential cell corresponding to the first differential transistor cell of the transconductance amplifier, the output current signal having a linear relationship with a transconductance value of the second differential cell as the driving voltage varies; generating a reference current signal having a linear relationship with a differential input voltage; comparing the output current signal and the reference current signal for adjusting the driving voltage value; and modifying the transconductance value of the second differential cell up to a balance of the current signals.