Abstract: A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.