Abstract: Systems and methods for tumor ablation with controlled precision of a temperature profile utilizing a tumor ablation probe device may include disposing a distal end of the tumor ablation probe device in a tissue, the distal end including a plurality of electrothermal modules (ETMs) on probe arm(s), each ETM including a first surface component electrically connected to a second surface component; supplying a first voltage of a first polarity or a second voltage of a second polarity to at least one ETM, and repeatedly alternating between the first polarity and the second polarity based on a time sequence cycle. When the first polarity is supplied, the ETM heats the first surface component and cools the second surface component, and when the second polarity is supplied, the ETM cools the first surface component and heats the second surface component. Each ETM and/or probe arm is configured for independent control.