Abstract: A method and system for processing a 3D tissue sample is provided, comprising the steps of receiving a tube with an inner space and two open ends, wherein the tube is configured to retain the 3D tissue sample in the inner space, arranging the tube so that one of the two open ends of the tube is located at a fluid channel, and forcing or actively pressing a tissue processing agent through the fluid channel and into the tube so that the tissue processing agent passes through the tissue.

Abstract: The invention relates to a printing control device (10) to control printing of a cover layer on a tissue or cell sample to be examined, a system (1) for printing of a cover layer (1) on a tissue or cell sample to be examined, a method to control printing of a cover layer on a tissue or cell sample to be sample to be examined, a computer program element for controlling such device or system for performing such method and a computer readable medium having stored such computer program element. The printing control device (10) comprises an imaging unit (11) and a printing control unit (12). The imaging unit (11) is configured to provide image data of the sample, and to determine a local image parameter from the image data. The local image parameter relates to local tissue porosity and/or a local capillary force of the sample. The printing control unit (12) is configured to control a printing parameter for printing the cover layer on the sample based on the local image parameter.

Abstract: The invention relates to a printing control device (10) to control printing of a cover layer on a tissue or cell sample to be examined, a system (1) for printing of a cover layer (1) on a tissue or cell sample to be examined, a method to control printing of a cover layer on a tissue or cell sample to be sample to be examined, a computer program element for controlling such device or system for performing such method and a computer readable medium having stored such computer program element. The printing control device (10) comprises an imaging unit (11) and a printing control unit (12). The imaging unit (11) is configured to provide image data of the sample, and to determine a local image parameter from the image data. The local image parameter relates to local tissue porosity and/or a local capillary force of the sample. The printing control unit (12) is configured to control a printing parameter for printing the cover layer on the sample based on the local image parameter.

Abstract: The invention relates to a method and a sample separation device (400) for the separation of material from a region of interest, the “sample-ROI” (RS), in a biological sample (11). An embodiment of the invention comprises the application of a structured cover sheet (20) that has an aperture (24) at the sample-ROI to the sample (11). Sample material can then selectively be removed from the sample-ROI through the aperture (24) in the cover sheet. The cover sheet (20) may for example be a tape with an adhesive on one side. The aperture (24) in the cover sheet (20) may automatically be cut out after the selection of a region of interest in a (microscopic) image (I) of the sample. Alternatively, the structured cover sheet (20) maybe produced by printing or plotting. Moreover, sample material may preferably be removed by lysing and may further be subjected to molecular diagnostics (MDx).

Abstract: The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids.