Patents by Inventor Danielle Hirsch

Danielle Hirsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of binding of charged species using PH- or potential-sensitive probes
    Patent number: 7056653
    Abstract: The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: June 6, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yechezkel Barenholz, Danielle Hirsch-Lerner, Rivka Cohen, Arie Dagan, Shimon Gatt
  • Detection of binding of charged species using pH- or potential-sensitive probes
    Publication number: 20020012923
    Abstract: The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 31, 2002
    Inventors: Yechezkel Barenholz, Danielle Hirsch-Lerner, Rivka Cohen, Arie Dagan, Shimon Gatt
  • Method of making calcification-resistant bioprosthetic tissue
    Patent number: 5746775
    Abstract: A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The biomaterial, preferably glutaraldehyde-pretreated, is subjected to an aqueous solution of 60% to 80% lower aliphatic alcohol, such as ethanol for a period of at least 20 minutes, and preferably, 24 to 72 hours. The biomaterial is rinsed, and then stored in either a glutaraldehyde-free environment or an ethanolic solution of glutaraldehyde. In some embodiments, the treatment solutions include an additional anticalcification agent which may be a soluble salt of a metallic cation, such as Al.sup.+3 or Fe.sup.+3.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: May 5, 1998
    Assignee: The Board of Regent6s of the University of Michigan
    Inventors: Robert J. Levy, Danielle Hirsch
  • Process for the stereospecific preparation of 24(R),25- and 24(S),25-dihydroxycholecalciferol and novel intermediates used therefor
    Patent number: 4758382
    Abstract: A novel process for the stereospecific preparation of a 24(R),25- and 24(S),25-dihydroxycholecalciferol. Also provided are novel intermediates used in the above process, being 22-p-toluenesulfonyl derivatives of 23,24,25,26,27-pentanorcholecalciferol and of 24(R)- and 24(S),25-dihydroxycholecalciferol.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: July 19, 1988
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Jeffrey Sterling, Ben-Zion Weiner, Dinora Barasch, Danielle Hirsch, Eliot Slovin