Abstract: A method for reprogramming differentiated or partially differentiated cells to a less differentiated or dedifferentiated state, which method includes providing a karyoplast of a differentiated or partially differentiated cell; and a source of multinucleate, aneuploid, euploid or polyploid multipotent or pluripotent cells, or morula or early embryos, or derivatives thereof; and placing the karyoplast in intimate contact with the multipotent or pluripotent cells, or morula or early embryos or derivatives thereof under conditions sufficient to permit at least partial reprogramming of the cells.