Patents by Inventor Danilo Maddalo

Danilo Maddalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS COMPRISING A SHP2 INHIBITOR AND A PD-LI BINDING ANTAGONIST
    Publication number: 20250312339
    Abstract: Provided herein are combination therapies comprising a SHP2 inhibitor (e.g., Compound 1) and a PD-L1 binding antagonist (e.g., atezolizumab) and methods of using such combination therapies.
    Type: Application
    Filed: May 12, 2023
    Publication date: October 9, 2025
    Inventors: Jennifer Eng-Wong, Pablo Saenz-Lopez Larrocha, Jeffrey Lau, Nicole Sodir, Joanne Irene Adamkewicz, Danilo Maddalo, Mark Andrew Merchant, Gaurav Pathria
  • PHARMACEUTICAL COMBINATION COMPRISING TNO155 AND A KRASG12C INHIBITOR
    Publication number: 20220152026
    Abstract: The present invention relates to a pharmaceutical combination comprising TNO155 and a KRASG12C inhibitor; pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of conditions in a SHP2 inhibitor combined with KRASG12C inhibition is beneficial in, for example, the treatment of cancers.
    Type: Application
    Filed: February 10, 2020
    Publication date: May 19, 2022
    Inventors: Saskia Maria Brachmann, Danilo Maddalo, Anirudh Cadapa Prahallad
  • BAG-1 PEPTIDE THAT INHIBITS PROSTATE CANCER
    Publication number: 20110190218
    Abstract: The present invention relates to a polypeptide having antitumor properties, to a vector encoding said polypeptide, to a host cell containing said vector, to uses of said polypeptide in the manufacture of a medicament for the treatment of cancer in patients, to a method comprising binding said polypeptide to molecular chaperones, and to a pharmaceutical composition containing said polypeptide.
    Type: Application
    Filed: July 28, 2009
    Publication date: August 4, 2011
    Applicant: KARLSRUHE INSTITUTE OF TECHNOLOGY
    Inventors: Andrew C. B. Cato, Liubov Shatkina, Katja Jehle, Danilo Maddalo