Patents by Inventor Danming TANG

Danming TANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240344013
    Abstract: Provided herein are methods for quantifying the concentration of multiple metabolites in a sample. Also provided are methods for relative quantification of multiple metabolites in a sample, methods for monitoring the course of a cell culture, and methods for optimising a cell culture.
    Type: Application
    Filed: March 13, 2024
    Publication date: October 17, 2024
    Applicant: Genentech, Inc.
    Inventors: Zijuan LAI, Shahram MISAGHI, Dewakar SANGARAJU, Danming TANG
  • Publication number: 20240240175
    Abstract: The presently disclosed subject matter relates to combinatorial vector cloning and transfection strategies for the generation of targeted integration host cells suitable for the expression of recombinant proteins, as well as targeted integration host cells generated by said strategies and compositions comprising said targeted integration host cells.
    Type: Application
    Filed: January 12, 2024
    Publication date: July 18, 2024
    Applicant: GENENTECH, INC.
    Inventors: Shahram Misaghi, Danming Tang, Brad Snedecor
  • Publication number: 20240190944
    Abstract: The present disclosure relates to cells (e.g., Chinese Hamster Ovary (CHO) cells) that are modified to reduce or eliminate the expression of certain endogenous cellular proteins, and methods of using such cells in the production of a recombinant product of interest, e.g., a recombinant protein, a recombinant viral particle, or a recombinant viral vector. These modifications were specifically chosen to generate engineered cells with desired traits in several key areas, including improved cell culture performance (e.g., higher viability and product titers).
    Type: Application
    Filed: November 20, 2023
    Publication date: June 13, 2024
    Applicant: Genentech, Inc.
    Inventors: Shahram MISAGHI, Brian Megia Castellano, Danming Tang, Avi J. Ashkenazi, Bradley R. Snedecor
  • Publication number: 20220041672
    Abstract: The present disclosure relates to eukaryotic cell lines with a stable integrated loss-of-function or attenuation-of-function mutation in each of the Bax and Bak genes. Also provided are methods of producing such cell lines. This disclosure also relates to compositions and cell cultures comprising such cell lines, as well as methods of producing a product, such as a recombinant polypeptide or viral vector, using said cells, compositions and cell cultures.
    Type: Application
    Filed: June 23, 2021
    Publication date: February 10, 2022
    Applicant: GENENTECH, INC.
    Inventors: Shahram MISAGHI, Danming TANG, Amy SHEN, Michael LAIRD