Abstract: A safety syringe includes a means for retracting a used needle within the syringe, sealing the syringe and locking the plunger in a retracted position requiring only conventional syringe manipulation. Accidental contact with a used needle or syringe contents is thereby prevented such that the syringe can be safely discarded in a conventional manner. A needle clamp augmentation to the front surface of the syringe plunger is engageable with the needle head portion of a hollow needle releasingly mounted to the syringe. A sealant cavity formed proximate to the needle end of the syringe contains a sealing compound. A sealant cavity cover prevents migration of the sealing compound into the syringe cylinder. Fully depressing the plunger causes the needle clamp to engage the needle head portion. Retracting the plunger dislodges and retracts the needle, drawing a sealing means about the gap left by the retracted needle and preventing fluid leakage.