Patents by Inventor Danny CHUI

Danny CHUI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE
    Publication number: 20250339552
    Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
    Type: Application
    Filed: June 24, 2025
    Publication date: November 6, 2025
    Inventors: James R. RICH, Stuart Daniel BARNSCHER, Mark Edmund PETERSEN, Raffaele COLOMBO, Michael G. BRANT, Manuel Michel Auguste LASALLE, Rupert H. DAVIES, Dunja UROSEV, Sukhbir Singh KANG, Peter Wing Yiu CHAN, Samir DAS, Andrea HERNANDEZ ROJAS, Robert William GENE, Ada G. H. YOUNG, Samuel Oliver LAWN, Danny CHUI, Duncan BROWMAN, Brandon CLAVETTE
  • Antibody-drug conjugates targeting folate receptor alpha and methods of use
    Patent number: 12433952
    Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
    Type: Grant
    Filed: May 29, 2024
    Date of Patent: October 7, 2025
    Assignee: Zymeworks BC Inc.
    Inventors: James R. Rich, Stuart Daniel Barnscher, Mark Edmund Petersen, Raffaele Colombo, Michael G. Brant, Manuel Michel Auguste Lasalle, Rupert H. Davies, Dunja Urosev, Sukhbir Singh Kang, Peter Wing Yiu Chan, Samir Das, Andrea Hernandez Rojas, Robert William Gene, Ada G. H. Young, Samuel Oliver Lawn, Danny Chui, Duncan Browman, Brandon Clavette
  • ANTI-NAPI2B ANTIBODIES AND METHODS OF USE
    Publication number: 20250277030
    Abstract: Described herein are antibody constructs that bind human NaPi2b (or SLC34A2) and antibody-drug conjugates (ADCs) comprising an anti-NaPi2b antibody construct conjugated to a drug, such as a cytotoxin or an immune modulator, and their use as therapeutics or diagnostics, for example, in the treatment or diagnosis of cancer.
    Type: Application
    Filed: March 28, 2025
    Publication date: September 4, 2025
    Inventors: Grant Raymond Wickman, James R. Rich, Andrea Hernandez Rojas, Eric ESCOBAR-CABRERA, Robert William Gene, Stuart Daniel Barnscher, Samuel Oliver Lawn, Sukhbir Singh Kang, Danny Chui, Brandon Clavette, Duncan Browman, Gesa Volkers
  • ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE
    Publication number: 20250235548
    Abstract: Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human sodium-dependent phosphate transporter 2B (NaPi2b) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
    Type: Application
    Filed: April 7, 2025
    Publication date: July 24, 2025
    Inventors: James R. Rich, Grant Raymond Wickman, Stuart Daniel Barnscher, Andrea Hernandez Rojas, Eric ESCOBAR-CABRERA, Michael G. Brant, Raffaele Colombo, Samir Das, Manuel Michel Auguste Lasalle, Mark Edmund Petersen, Robert William Gene, Samuel Oliver Lawn, Sukhbir Singh Kang, Danny Chui, Brandon Clavette, Duncan Browman, Gesa Volkers, Dunja Urosev
  • ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE
    Publication number: 20240424125
    Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
    Type: Application
    Filed: May 29, 2024
    Publication date: December 26, 2024
    Inventors: James R. RICH, Stuart Daniel BARNSCHER, Mark Edmund PETERSEN, Raffaele COLOMBO, Michael G. BRANT, Manuel Michel Auguste LASALLE, Rupert H. DAVIES, Dunja UROSEV, Sukhbir Singh KANG, Peter Wing Yiu CHAN, Samir DAS, Andrea HERNANDEZ ROJAS, Robert William GENE, Ada G. H. YOUNG, Samuel Oliver LAWN, Danny CHUI, Duncan BROWMAN, Brandon CLAVETTE
  • ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF
    Publication number: 20230265202
    Abstract: Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FR? antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.
    Type: Application
    Filed: April 9, 2021
    Publication date: August 24, 2023
    Inventors: Daniel T. PATTON, Lee FREIBURGER, Thomas SPRETER VON KREUDENSTEIN, David M. MILLS, Gesa VOLKERS, Dunja UROSEV, Zhuang DUAN, Elizabeth HALVORSEN, Harsh PRATAP, Brandon CLAVETTE, Anna VON ROSSUM, Patricia ZWIERZCHOWSKI, Peter Wing Yiu CHAN, Danny CHUI, Sylwia JANCOWSKI, Sukhbir Singh KANG, Grant Raymond Wickman
  • ANTIBODY CONSTRUCTS BINDING 4-1BB AND TUMOR-ASSOCIATED ANTIGENS AND USES THEREOF
    Publication number: 20230052369
    Abstract: Described herein are antibody constructs comprising a 41-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-1BB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function.
    Type: Application
    Filed: April 9, 2021
    Publication date: February 16, 2023
    Inventors: Daniel T. PATTON, David M. MILLS, Thomas SPRETER VON KREUDENSTEIN, Gesa VOLKERS, Dunja UROSEV, Lee FREIBURGER, Zhuang DUAN, Elizabeth HALVORSEN, Harsh PRATAP, Brandon CLAVETTE, Anna VON ROSSUM, Duncan BROWMAN, Peter Wing Yiu CHAN, Danny CHUI, Robert William GENE, Sylwia JANCOWSKI, Sukhbir Singh KANG, Patricia ZWIERZCHOWSKI