Abstract: A system for determining a solubility of a substance comprises a holder to hold a sample comprising an amount of the substance and an amount of the solvent system. The system further comprises a temperature conditioner to alter a temperature of the sample, an optical measurement device to measure an optical parameter of the sample and a control device to control at least the temperature conditioner and the optical measurement device. The control device may be programmed to alter the temperature of the sample by the temperature conditioner, measure the optical parameter of the sample by the optical measurement device, and determine the solubility of the substance from a change of the optical parameter of the sample as a function of the temperature.

Abstract: The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being provided with a filter having pores, which filter is arranged at a distance below the open upper end, each of the wells having an upper inner wall part above the filter that has a fluid contact surface and each filter having a top filter surface, at least both the fluid contact surface of the well and the top filter surface being of a material that is at least substantially inert for organic and/or aqueous solvents and/or mixtures of organic and aqueous solvents, providing one or more substances and one or more solvents in at least one of the wells of the well plate, applying conditions to dissolve the one or more substances in the one or more solvents; applying conditions for crystallizing at least a part of the su