Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymeric encapsulating binder, and an active agent having limited water solubility dissolved or dispersed in a solvent. An aqueous second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The two phases are separated. The discontinuous first phase is washed with water, or an aqueous solution of water and a solvent for residual solvent in the first phase, to reduce the level of residual solvent in the microparticles to less than about 2% by weight of the microparticles. Also disclosed are a microencapsulated drug prepared by the method for preparing biodegradable, biocompatible microparticles, and a pharmaceutical composition that includes biodegradable and biocompatible microparticles in a pharmaceutically acceptable carrier.

Abstract: A delivery system for providing antiparasitic agents to animals is provided and a method of treating parasitic infections in animals using such delivery systems is described. The delivery system is particularly useful for treatment with avermectins and milbemycins in lactide/glycolide polymeric matrices.

Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: A delivery for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament.

Abstract: A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament.

Abstract: A nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia includes a load bearing member formed from a plurality of biocompatible polyolefin fibers positioned at angles of from 0.degree. to 55.degree. relative to the longitudinal axis of the load bearing member. Each fiber is less than 100 microns in diameter and has a tensile strength greater than or equal to about 50,000 psi. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to provide shape for the load bearing member. A sheath may be friction fit or molded onto the exterior of the load bearing member to prevent abrasion of the fibers.

Abstract: This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.

Abstract: A fibrous article is formed of a polymer composition which incorporates povidone-iodine and provides for its sustained release.

Abstract: An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microcapsules containing said active agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.