Patents by Inventor Danny Lewis
Danny Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9789196Abstract: The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.Type: GrantFiled: April 21, 2015Date of Patent: October 17, 2017Assignee: ANTRIABIO, INC.Inventors: Kenneth Hinds, Danny Lewis, Paul Schmidt, Kathleen M. Campbell
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Patent number: 9556992Abstract: An apparatus for installing multiple utility meters is provided. The apparatus may be attachable to an existing setter in place of a utility meter. The apparatus includes connectors for a plurality of utility meters, wherein one of the utility meters attaches such that intake into the meter and outtake out of the meter utilize the setter. The apparatus may include connectors for one or more additional meters and secondary outtakes for each of the additional meters.Type: GrantFiled: March 3, 2015Date of Patent: January 31, 2017Inventors: Steven Josh Collins, Danny Lewis Young
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Publication number: 20150216995Abstract: The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.Type: ApplicationFiled: April 21, 2015Publication date: August 6, 2015Inventors: Kenneth Hinds, Danny Lewis, Paul Schmidt, Kathleen M. Campbell
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Patent number: 9040664Abstract: The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.Type: GrantFiled: April 8, 2004Date of Patent: May 26, 2015Assignee: AntriaBio, Inc.Inventors: Kenneth Hinds, Danny Lewis, Paul Schmidt, Kathleen M. Campbell
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Publication number: 20080292712Abstract: Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.Type: ApplicationFiled: August 5, 2008Publication date: November 27, 2008Applicant: PR PHARMACEUTICALS, INC.Inventors: Danny Lewis, Paul Schmidt, Kenneth Hinds
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Publication number: 20080032245Abstract: Embodiments of the present invention provide a fuel supply system for combustion engines, whereby the temperatures of an oxidizer and fuel may be increased so that the temperatures approach but do not achieve an auto-ignition temperature for the fuel charge. The fuel charge may result in substantial improvements in fuel efficiency.Type: ApplicationFiled: October 12, 2007Publication date: February 7, 2008Applicant: VAPOR FUEL TECHNOLOGIES, LLCInventors: Raymond Bushnell, Anthony Dean, Danny Lewis, Marcus DeHaas
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Publication number: 20070083006Abstract: The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB 1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.Type: ApplicationFiled: April 8, 2004Publication date: April 12, 2007Applicant: PR Pharmaceuticals, Inc.Inventors: Kenneth Hinds, Danny Lewis, Paul Schmidt, Kathleen Campell
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Publication number: 20070062503Abstract: A fuel supply assembly is provided that may allow for use of vaporized fuel to power an engine and enhance fuel efficiency. The fuel supply assembly may include a vaporizing tank, a heating source, a temperature control and a monitoring and control system configured to control intermixing of ambient air and vaporized gasoline to maintain a desired hydrocarbon level in an exhaust.Type: ApplicationFiled: May 7, 2004Publication date: March 22, 2007Inventors: Raymond Bushnell, Danny Lewis, Robert Parry
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Publication number: 20060127482Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.Type: ApplicationFiled: October 28, 2005Publication date: June 15, 2006Inventors: Jason Fewell, Majed Matar, Jennifer Rice, Danny Lewis, Khursheed Anwer
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Publication number: 20050276859Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.Type: ApplicationFiled: May 16, 2005Publication date: December 15, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Michael Rickey, J. Ramstack, Danny Lewis
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Publication number: 20050145226Abstract: A fuel supply assembly providing vaporized fuel to an engine wherein a quantity of liquid gasoline fuel is controllably heated for a desired vapor emission from the liquid fuel, and a conduit arrangement conducts the vapor, intermixes it with ambient air and conveys the intermixture to the engine's combustion chamber. A sensor in the engine exhaust monitors the hydrocarbon content of the exhaust and control valving controls the vapor to air intermixture in response to the monitor for maintaining a desired intermixture that produces the desired hydrocarbon content.Type: ApplicationFiled: March 4, 2005Publication date: July 7, 2005Inventors: Raymond Bushnell, Danny Lewis
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Publication number: 20050098161Abstract: A fuel supply assembly is provided that may allow for use of vaporized fuel to power an engine and enhance fuel efficiency. The fuel supply assembly may include a vaporizing tank, a heating source, a temperature control and a monitoring and control system configured to control intermixing of ambient air and vaporized gasoline to maintain a desired hydrocarbon level in an exhaust.Type: ApplicationFiled: November 11, 2003Publication date: May 12, 2005Inventors: Raymond Bushnell, Danny Lewis, Robert Parry
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Publication number: 20040185103Abstract: Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.Type: ApplicationFiled: January 27, 2004Publication date: September 23, 2004Inventors: Danny Lewis, Paul Schmidt, Kenneth Hinds
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Patent number: 6706289Abstract: Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.Type: GrantFiled: October 31, 2001Date of Patent: March 16, 2004Assignee: PR Pharmaceuticals, Inc.Inventors: Danny Lewis, Paul Schmidt, Kenneth Hinds
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Publication number: 20020155158Abstract: Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.Type: ApplicationFiled: October 31, 2001Publication date: October 24, 2002Inventors: Danny Lewis, Paul Schmidt, Kenneth Hinds