Patents by Inventor Danny McGee

Danny McGee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Publication number: 20060013860
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: September 12, 2005
    Publication date: January 19, 2006
    Applicant: Medarex, Inc.
    Inventors: Howard Ng, Danny McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver Saunders, Irina Astafieva
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Publication number: 20050272798
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: June 21, 2005
    Publication date: December 8, 2005
    Applicant: Medarex, Inc.
    Inventors: Howard Ng, Zhihong Li, Danny McGee, Oliver Saunders, Guoxian Wu, David King, Valeri Martichonok, Sharon Boyd, Thomas Lobl
  • Method for solution phase synthesis of oligonucleotides
    Publication number: 20040116685
    Abstract: This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
    Type: Application
    Filed: July 17, 2001
    Publication date: June 17, 2004
    Applicant: Proligo LLC
    Inventors: Wolfgang Pieken, Danny McGee, Alecia Settle, Yansheng Zhai, Jianping Huang
  • Bioconjugation of macromolecules
    Patent number: 6737236
    Abstract: This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition reactions, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: May 18, 2004
    Assignee: Proligo, LLC
    Inventors: Wolfgang Pieken, Ken Hill, Bruce Eaton, Danny McGee, Kurt Vagle, Larry Gold, Andrew Stephens
  • Method for solution phase synthesis of oligonucleotides
    Patent number: 6262251
    Abstract: This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: July 17, 2001
    Assignee: Proligo LLC
    Inventors: Wolfgang Pieken, Danny McGee, Alecia Settle, Yansheng Zhai, Jianping Huang