Patents by Inventor Danny McGee

Danny McGee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180008416
    Abstract: A multi-layered prosthetic element comprises a central body (1; 1?) of a substantially truncated conical shape and having a through axial cavity (2; 2?) open at both ends which gives the central body (1; 1?) a ring-shaped cross-section. The central body (1, 1?) comprises an outer portion (110; 110?), made of trabecular metal material, an inner portion (130; 130?), made of trabecular metal material, and an intermediate portion (120; 120?) made of metal material without significant porosity. The outer portion (110; 110?) and the inner portion (130; 130?) are integrally connected to the intermediate portion (120; 120?). The intermediate portion (120; 120?) is configured to mechanically resist to stresses transmitted to the inner portion (130; 130?) on one side and to the outer portion (110; 110?) on the other side.
    Type: Application
    Filed: March 24, 2015
    Publication date: January 11, 2018
    Inventors: Enoc VERGARI, Massimiliano BERNARDONI, Francesco SICCARDI, Alberto SICCARDI, David MANNING, Dannis MCGEE
  • Publication number: 20060013860
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: September 12, 2005
    Publication date: January 19, 2006
    Applicant: Medarex, Inc.
    Inventors: Howard Ng, Danny McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver Saunders, Irina Astafieva
  • Publication number: 20050272798
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: June 21, 2005
    Publication date: December 8, 2005
    Applicant: Medarex, Inc.
    Inventors: Howard Ng, Zhihong Li, Danny McGee, Oliver Saunders, Guoxian Wu, David King, Valeri Martichonok, Sharon Boyd, Thomas Lobl
  • Publication number: 20040116685
    Abstract: This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
    Type: Application
    Filed: July 17, 2001
    Publication date: June 17, 2004
    Applicant: Proligo LLC
    Inventors: Wolfgang Pieken, Danny McGee, Alecia Settle, Yansheng Zhai, Jianping Huang
  • Patent number: 6737236
    Abstract: This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition reactions, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: May 18, 2004
    Assignee: Proligo, LLC
    Inventors: Wolfgang Pieken, Ken Hill, Bruce Eaton, Danny McGee, Kurt Vagle, Larry Gold, Andrew Stephens
  • Patent number: 6262251
    Abstract: This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: July 17, 2001
    Assignee: Proligo LLC
    Inventors: Wolfgang Pieken, Danny McGee, Alecia Settle, Yansheng Zhai, Jianping Huang