Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.

Abstract: This disclosure is directed to computing services that provide secure network connections using public-private key-based security for Internet of Things (IoT) devices, such as voice devices, that may have more than a predefined set of users. Device certificates that authorize IoT devices to access a secure network, such as an enterprise network and/or services eternal to an enterprise network are provided. A setup system may cooperate with an IoT device and a subordinate CA to generate a device certificate that allows the IoT device to access a secure enterprise network and services outside of the secure enterprise network. The IoT device may generate a certificate signing request (CSR) which may be signed by a remote subordinate CA to generate the device certificate using a root certificate of an enterprise CA. Systems are also disclosed that renew certificates for the IoT devices prior to their expiration.

Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.

Abstract: A cover system that may be used for protection of a device such as a smart phone, tablet, or the like. The system includes a body and a cover. The cover may be arranged in a first configuration where the cover is engaged with a first side of the body or a second configuration where the cover is engaged with a second side of the body. The cover may be removable from the body for converting between the first configuration and the second configuration. In the first configuration, the cover may be arranged on a rear of the body and in the second configuration, the cover may be arranged on a front of the body to protect a display of a device retained within the body. As such, additional protection may be selectively provided to the front of a device (e.g., near the display of the device).

Abstract: A cover system that may be used for protection of a device such as a smart phone, tablet, or the like. The system includes a body and a cover. The cover may be arranged in a first configuration where the cover is engaged with a first side of the body or a second configuration where the cover is engaged with a second side of the body. The cover may be removable from the body for converting between the first configuration and the second configuration. In the first configuration, the cover may be arranged on a rear of the body and in the second configuration, the cover may be arranged on a front of the body to protect a display of a device retained within the body. As such, additional protection may be selectively provided to the front of a device (e.g., near the display of the device).

Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task-level lighting for task areas in the controlled area, where each task area is a separate sub-area of the controlled area.

Abstract: An oral solid dosage form containing nanoparticles is made by (a) reducing the particle size of at least one pharmaceutically active ingredient dispersed in a solution containing fish gelatin to form a nanosuspension and (b) freeze-drying the nanosuspension of step (a) to form the oral solid dosage form.

Abstract: Described herein are nasal devices, including nasal devices formed in layers having four or fewer layers. In some variations, the nasal devices include a single integrated layer from which the flap of the airflow resistor is formed as well as the base of the holdfast region. The nasal devices may include a single aligner or rim body on the side of the device facing the subject. The aligner may protect the airflow resistor, and may help center or position the nasal device. In some variations, these nasal devices may include a noise-reduction feature. Also described herein are systems, devices and methods for determining if a passive nasal respiratory device having an airflow resistor configured to inhibit exhalation more than inhalation has been worn by a subject, and thereby confirming compliance.

Abstract: Described herein are combined active PAP/passive EPAP interface devices to transmit positive air pressure from a PAP source to the user, but provide passive EPAP when the PAP source is disabled. These interface device may continue to provide benefit to the user even if the PAP source becomes disconnected or otherwise fails. The interface devices described herein include a passive EPAP airflow resistor configured to provide expiratory positive airway pressure (“EPAP”). These interface devices may also include quick connects and/or disconnects for releasably connecting to the source of pressurized breathable gas, a quick release for disconnecting from the source of pressurized breathable gas, and an adhesive user interface region that connects the device the user's face. Also described are adapter for converting a PAP interface devices into combined active PAP/passive EPAP interface devices, and methods of using these devices.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task-level lighting for task areas in the controlled area, where each task area is a separate sub-area of the controlled area.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task level lighting for task areas in the controlled area, wherein each task area is a separate sub-area of the controlled area.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task level lighting for task areas in the controlled area, wherein each task area is a separate sub-area of the controlled area.

Abstract: Described herein are nasal devices, including nasal devices formed in layers having four or fewer layers. In some variations, the nasal devices include a single integrated layer from which the flap of the airflow resistor is formed as well as the base of the holdfast region. The nasal devices may include a single aligner or rim body on the side of the device facing the subject. The aligner may protect the airflow resistor, and may help center or position the nasal device. In some variations, these nasal devices may include a noise-reduction feature. Also described herein are systems, devices and methods for determining if a passive nasal respiratory device having an airflow resistor configured to inhibit exhalation more than inhalation has been worn by a subject, and thereby confirming compliance.

Abstract: Described herein are passive nasal device having a resistance to exhalation that is greater than the resistance to inhalation. Also described are devices, methods and systems for sensing and measuring intranasal pressure when a subject is wearing a passive nasal respiratory device that is configured to inhibit exhalation more than inhalation. Also described are adapters for nasal devices and methods of using a nasal device adapter. Adapters may be used so that a passive nasal device may be applied indirectly in communication with a subject's nose; in some variations this may allow the passive nasal device to be re-used. Also described herein are nasal devices having a billowing airflow resistor that is configured to have a greater resistance to exhalation than to inhalation.

Abstract: Described herein are layered nasal devices including layered nasal devices having one or more stiffening members supporting the holdfast region of the nasal device. The stiffening member may be a stress-distributing member or a separate stress-distributing element or member may be included. In some variations the layered nasal device includes a stress distributing element to help prevent wrinkling, de-laminating, buckling, or otherwise disrupting the shape and/or activity of the nasal device. Also described herein are delayed resistance adapters that may be used with a nasal devices that inhibit exhalation more than inhalation (including, but not limited to the adhesive nasal devices described herein). A delayed resistance adapter may be activated to suspend or bypass the increased expiratory resistance of the nasal device. Suspending the increased expiratory resistance may allow the user to allow a user to acclimate to the use of the nasal device.